The loss of Fc surface receptors by erythroleukemic cells following stimulation to differentiate
| Autor: | Curtis L. Parker, W. Craig Hooper |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Leukemia
Experimental Rosette Formation biology Fc receptor Gamma globulin Stimulation Cell Differentiation Receptors Fc Cell biology Cell Line Friend murine leukemia virus Mice Tumor Virus Infections Antigen Precursor cell Immunology biology.protein Animals Dimethyl Sulfoxide Leukemia Erythroblastic Acute Progenitor cell Antibody Receptor Developmental Biology |
| Zdroj: | Cell differentiation. 8(5) |
| ISSN: | 0045-6039 |
| Popis: | Uninduced Friend virus-infected erythroleukemic cells (FLC) have been shown to carry the Fc receptor for immunoglobulin when assayed for their ability to form rosettes with antibody-coated sheep erythrocytes (EA-IgG). Cells induced to differentiate with dimethylsulfoxide (Me 2 SO), ultimately lose the ability to form rosettes with EA-IgG. Hence, it appears that the ability of FLC to form rosettes with EA-IgG is due to the precursor cell surface components which are either masked or lost following Me 2 SO-mediated induction as mature erythrocyte-specific membrane antigens appear. This suggestion is supported by a decrease in the number of Friend progenitor cells capable of binding fluorescein-conjugated antibodies, produced in rabbits against mouse gamma globulin, following Me 2 SO-induced differentiation. |
| Databáze: | OpenAIRE |
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