Obesity is associated with lower coronary microvascular density
| Autor: | Mary Jane Black, Darren J. Kelly, David L. Prior, Duncan J. Campbell, Jithendra B. Somaratne, James F. Kenny, Michael Yii, Andrew Newcomb |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Increased pulmonary capillary wedge pressure
Male Risk medicine.medical_specialty Diastole lcsh:Medicine Coronary circulation Ventricular Dysfunction Left Internal medicine Coronary Circulation medicine Pressure Humans Myocardial infarction Obesity lcsh:Science Heart Failure Multidisciplinary business.industry lcsh:R Microvascular Density Atrial fibrillation Middle Aged medicine.disease medicine.anatomical_structure Heart failure Microvessels Cardiology Female lcsh:Q business Artery Research Article |
| Zdroj: | PLoS ONE, Vol 8, Iss 11, p e81798 (2013) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND: Obesity is associated with diastolic dysfunction, lower maximal myocardial blood flow, impaired myocardial metabolism and increased risk of heart failure. We examined the association between obesity, left ventricular filling pressure and myocardial structure. METHODS: We performed histological analysis of non-ischemic myocardium from 57 patients (46 men and 11 women) undergoing coronary artery bypass graft surgery who did not have previous cardiac surgery, myocardial infarction, heart failure, atrial fibrillation or loop diuretic therapy. RESULTS: Non-obese (body mass index, BMI, ≤ 30 kg/m(2), n=33) and obese patients (BMI >30 kg/m(2), n=24) did not differ with respect to myocardial total, interstitial or perivascular fibrosis, arteriolar dimensions, or cardiomyocyte width. Obese patients had lower capillary length density (1145 ± 239, mean ± SD, vs. 1371 ± 333 mm/mm(3), P=0.007) and higher diffusion radius (16.9 ± 1.5 vs. 15.6 ± 2.0 μm, P=0.012), in comparison with non-obese patients. However, the diffusion radius/cardiomyocyte width ratio of obese patients (0.73 ± 0.11 μm/μm) was not significantly different from that of non-obese patients (0.71 ± 0.11 μm/μm), suggesting that differences in cardiomyocyte width explained in part the differences in capillary length density and diffusion radius between non-obese and obese patients. Increased BMI was associated with increased pulmonary capillary wedge pressure (PCWP, P |
| Databáze: | OpenAIRE |
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