Upregulation of microRNA-191 can serve as an independent prognostic marker for poor survival in prostate cancer
| Autor: | Yong-ji Yan, Xuetao Ma, Yan-feng Li, Jing Shi, Ya-bing Wu, Jing-bo Liu, Lin-feng Dai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Male medicine.medical_specialty China Laparoscopic radical prostatectomy medicine.medical_treatment Observational Study Bone Neoplasms survival microRNA-191 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Predictive Value of Tests Internal medicine expression Biomarkers Tumor Medicine Humans 030212 general & internal medicine Aged Neoplasm Staging Prostatectomy Oncogene business.industry Hazard ratio Cancer Prostatic Neoplasms General Medicine Middle Aged medicine.disease Prognosis prostate cancer Survival Analysis Up-Regulation Log-rank test Gene Expression Regulation Neoplastic MicroRNAs medicine.anatomical_structure 030220 oncology & carcinogenesis Lymphatic Metastasis T-stage Neoplasm Grading business prognostic marker Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | MicroRNA-191 (miR-191) has been identified as being upregulated in several types of cancers, and plays the role of oncogene. The expression of miR-191 has been found to be upregulated in prostate cancer tissues as well as cell lines. In this study, we analyzed the correlation of miR-191 expression with clinicopathologic factors and prognosis in prostate cancer. Prostate cancer tissue samples and adjacent normal prostate tissue samples were collected from 146 patients who underwent laparoscopic radical prostatectomy between April 2013 and March 2018. Student two-tailed t-test was used for comparisons of 2 independent groups. The relationships between miR-191 expression and different clinicopathological characteristics were evaluated using the Chi-squared test. Kaplan–Meier survival plots and log-rank tests were used to assess the differences in overall survival of the different subgroups of prostate cancer patients. miR-191 expression was significantly higher in prostate cancer tissues compared with normal adjacent prostate tissues (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|