Migraine and traumatic brain injury: a cohort study in Taiwan
| Autor: | Cong-Liang Zhang, Ying-Ju Su, Chieh-Hsin Wu, Hao Qin, Ming-Kung Wu, Li Zhang, Ying-Yi Lu, Qing-Rui Wang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Databases Factual Traumatic brain injury Migraine Disorders Population Taiwan Poison control Disease Global Health Risk Assessment 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Injury prevention Brain Injuries Traumatic medicine Humans migraine 030212 general & internal medicine Risk factor education Retrospective Studies education.field_of_study business.industry Research traumatic brain injury General Medicine Middle Aged medicine.disease Survival Rate Migraine Taiwan health programmes Population Surveillance Female Morbidity business 030217 neurology & neurosurgery Cohort study Follow-Up Studies |
| Zdroj: | BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | ObjectiveTraumatic brain injury is now a major contributor to the global healthcare burden. Migraine is another debilitating disease with a global health impact. While most researchers agree that traumatic brain injury is a risk factor for migraine, whether migraine is a risk factor for traumatic brain injury still remains under debate. We therefore aimed to investigate whether migraine was a risk factor for developing traumatic brain injury.Study designRetrospective population-based cohort study.SettingData for people who had been diagnosed with migraine were retrieved from Taiwan’s National Health Insurance Research Database.ParticipantsWe identified 7267 patients with newly diagnosed migraine during 1996–2010. The migraineurs to non-migraineurs ratio was set at 1:4 to enhance the power of statistical tests.Primary and secondary outcome measuresWe used multivariate Cox proportional hazard regression models to assess the effects of migraines on the risk of traumatic brain injury after adjusting for potential confounders.ResultsThe overall traumatic brain injury risk was 1.78 times greater in the migraine group compared with the non-migraine group after controlling for covariates. Additionally, patients with previous diagnoses of alcohol-attributed disease, mental disorders and diabetes mellitus had a significantly higher traumatic brain injury risk compared with those with no history of these diagnoses.ConclusionsThis study of a population-based database indicated that migraine is a traumatic brain injury risk factor. Greater attention to migraine-targeted treatment modalities may reduce traumatic brain injury-related morbidity and mortality. |
| Databáze: | OpenAIRE |
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