Pneumocystis carinii Pneumonia in the Acquired Immunodeficiency Syndrome
| Autor: | Lesser M, Choi Hs, Ok Hi Yoo, Desmond E, Cucco Ra |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.medical_treatment Lung biopsy Opportunistic Infections Acquired immunodeficiency syndrome (AIDS) medicine Animals Humans In patient Tolonium Chloride Saline Acquired Immunodeficiency Syndrome medicine.diagnostic_test Pneumocystis business.industry Pneumonia Pneumocystis Transbronchial lung biopsy General Medicine Middle Aged medicine.disease respiratory tract diseases Pneumonia Bronchoalveolar lavage Pneumocystis carinii business Bronchoalveolar Lavage Fluid |
| Zdroj: | Southern Medical Journal. 82:829-832 |
| ISSN: | 0038-4348 |
| DOI: | 10.1097/00007611-198907000-00008 |
| Popis: | Over a 30-month period, we evaluated 74 patients with acquired immunodeficiency syndrome (AIDS) for suspected opportunistic pulmonary infection. All had abnormal findings on chest roentgenogram. Sixty patients (81%) were found to have Pneumocystis carinii pneumonia (PCP). We assessed the yield of various diagnostic methods, and found that bronchoalveolar lavage samples obtained by the instillation of 20 to 50 ml of normal saline (minilavage) contained detectable organisms in 51 of 53 patients (sensitivity of 96%) when the samples were embedded in plastic, cut in thick sections (1 micron), stained with toluidine blue O, and evaluated by light microscopy. In comparison, the diagnostic yield was 94% for lung biopsy, 85% for touch preparation of lung tissue, 32% for bronchial washing, and 14% for brush biopsy. It is significant that minilavage samples embedded in plastic were positive in all seven patients who did not have transbronchial lung biopsy because they were at high risk for complications. We conclude that the process of embedding minilavage samples in plastic and evaluating thick sections stained with toluidine blue O is a sensitive method of diagnosing PCP in patients with AIDS. |
| Databáze: | OpenAIRE |
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