Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with MS
| Autor: | Vittorio Martinelli, Giuseppe Scotti, Bruno Colombo, Simone Spuler, Tarek A. Yousry, Adriana Campi, Raymond Voltz, G. Comi, C Kandziora, S. Bressi, Massimo Filippi |
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| Přispěvatelé: | Filippi, M, Yousry, T, Campi, A, Kandziora, C, Colombo, B, Voltz, R, Martinelli, V, Spuler, S, Bressi, S, Scotti, G, Comi, G |
| Rok vydání: | 1996 |
| Předmět: |
Gadolinium DTPA
Multiple Sclerosis Time Factors Gadolinium chemistry.chemical_element Contrast Media Central nervous system disease Lesion chemistry.chemical_compound medicine Organometallic Compounds Humans In patient cardiovascular diseases medicine.diagnostic_test Dose-Response Relationship Drug business.industry Multiple sclerosis Pentetic acid Magnetic resonance imaging Pentetic Acid medicine.disease Magnetic Resonance Imaging Dose–response relationship chemistry Spinal Cord cardiovascular system Neurology (clinical) medicine.symptom Nuclear medicine business |
| Zdroj: | Neurology. 46(2) |
| ISSN: | 0028-3878 |
| Popis: | We studied whether a triple dose of gadolinium-DTPA alone or in combination with delayed scanning increases the sensitivity of brain MRI for detecting enhancing lesions in patients with MS. We obtained T1-weighted brain MRI scans in two sessions for 22 patients with clinically definite MS. In the first session, we obtained one scan 5 to 7 minutes after the injection of 0.1 mmol/kg gadolinium-DTPA (standard dose). In the second session, 6 to 24 hours later, we obtained one scan before the two scans 5 to 7 minutes (for all patients) and one hour (for 11 patients) after the injection of 0.3 mmol/kg gadolinium-DTPA (triple dose). We detected 83 enhancing lesions in 14 patients when the standard dose of gadolinium-DTPA was used. The numbers of enhancing lesions increased to 138 (average increase 66%; p = 0.001) and the numbers of patients with such lesions to 18 (increase 28%) when we used the triple dose of gadolinium-DTPA. In addition, the total area per patient occupied by such lesions was greater (p < 0.0001) and lesion signal intensity higher (p = 0.0001) on the triple-dose scans than the standard-dose scans. There was an increase in the number of large enhancing lesions (p = 0.03) in the scans obtained 1 hour after the injection of the triple dose of gadolinium-DTPA. These data indicate that in patients with MS, a triple dose of gadolinium-DTPA can reveal many more enhancing lesions, which also appear larger. This suggests that the pathologic nature of "active" lesions in MS is heterogeneous, which might have impact on planning clinical trials. |
| Databáze: | OpenAIRE |
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