Kinesin Family Member 6 Variant Trp719Arg Does Not Associate With Angiographically Defined Coronary Artery Disease in the Ottawa Heart Genomics Study

Autor:	George A. Wells, Ruth McPherson, Heather Doelle, Li Chen, Robert Roberts, Rosemary LaRose, Kathryn J.H. Williams, Melanie Belanger, Sonny Dandona, Alexandre F.R. Stewart, Olivia Assogba, Gwen Ewart
Rok vydání:	2009
Předmět:	medicine.medical_specialty Kinesins Genomics Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Polymorphism Single Nucleotide Coronary artery disease 03 medical and health sciences 0302 clinical medicine Risk Factors Polymorphism (computer science) Internal medicine Humans Medicine SNP Myocardial infarction 030304 developmental biology 0303 health sciences business.industry medicine.disease Family member KIF6 Cardiology Kinesin Cardiology and Cardiovascular Medicine business
Zdroj:	Journal of the American College of Cardiology. 53:1471-1472
ISSN:	0735-1097
DOI:	10.1016/j.jacc.2008.12.051
Popis:	To the Editor: To date, the only common genetic variant to consistently associate with risk of coronary artery disease (CAD) or myocardial infarction (MI) is the 9p21.3 variant ([1,2][1]). Several recent reports identified a SNP (rs20455) that alters an amino acid in the KIF6 protein (Trp719Arg)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545be073efafd29967348188a01ef4ec https://doi.org/10.1016/j.jacc.2008.12.051 Zobrazit plný text záznamu