Neuro-Behçet's disease: epidemiology, clinical characteristics, and management
| Autor: | Desmond Kidd, Adnan Al-Araji |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Pathology business.industry Behcet Syndrome Cranial nerves Meningoencephalitis Disease Spinal cord medicine.disease Nervous System Dermatology medicine.anatomical_structure Peripheral nervous system Basal ganglia Dural venous sinuses medicine Humans Neurology (clinical) Nervous System Diseases Neuro-Behçet's disease business |
| Zdroj: | The Lancet Neurology. 8:192-204 |
| ISSN: | 1474-4422 |
| Popis: | Behçet's disease (BD) is a multisystem relapsing inflammatory disorder of unknown cause. In neuro-BD (NBD), the CNS can be involved in one or both of two ways: first, and most commonly, through the development of an immune-mediated meningoencephalitis, which predominantly involves the brainstem, but can also involve the basal ganglia, thalamus, cortex and white matter, spinal cord, or cranial nerves; and second, as a consequence of thrombosis within the dural venous sinuses. Headache is a common symptom in BD and does not necessarily indicate CNS involvement. Peripheral nervous system involvement is rare. New treatment options have recently become available, which have led to an improvement in morbidity after meningoencephalitis. Most of the reported studies on NBD are retrospective. Collaborative prospective studies of the natural history of the disease, particularly the nature and treatment of progressive neurological disease, and evidence-based studies of treatment are needed. |
| Databáze: | OpenAIRE |
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