Human milk secretory IgA antibody to nontypeable Haemophilus influenzae: Possible protective effects against nasopharyngeal colonization
| Autor: | Linda C. Duffy, Noboru Yamanaka, Deborah Krystofik, Judy Wolf, Yasuaki Harabuchi, Howard Faden |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Immunoglobulin A Biology Breast milk medicine.disease_cause Haemophilus influenzae Microbiology Nasopharynx medicine Humans Colonization Prospective Studies Milk Human Pasteurellaceae Infant Newborn biology.organism_classification Antibodies Bacterial Otitis Media Otitis Acute Disease Immunoglobulin A Secretory Pediatrics Perinatology and Child Health Immunology biology.protein Female medicine.symptom Antibody Breast feeding Bacterial Outer Membrane Proteins |
| Zdroj: | The Journal of Pediatrics. 124:193-198 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(94)70302-7 |
| Popis: | Sixty-eight children fed human milk were followed prospectively from birth to 12 months of age to assess the effect of milk antibody on nasopharyngeal colonization. Human milk secretory IgA antibody to P6, a highly conserved outer membrane protein of nontypeable Haemophilus influenzae, was measured with the use of an enzyme-linked immunosorbent assay. Nasopharyngeal colonization with nontypeable H. influenzae and the occurrence of otitis media were determined. Nasopharyngeal colonization was found in 22 children (32%), and 39 children (57%) had otitis media. Frequency of isolation of nontypeable H. influenzae was directly related to episodes of otitis media (r = 0.35; p = 0.001). The level of human milk anti-P6 secretory IgA antibody was inversely related to frequency of isolation of the organism (r = -0.27; p = 0.026). The average antibody level, expressed as nanograms per 0.1 mg total secretory IgA, in human milk fed to children with no colonization of nontypeable H. influenzae was significantly higher than in milk fed to children in whom colonization occurred on multiple occasions (156 +/- 120 vs 69 +/- 50; p = 0.013). Prevention of colonization was most evident during breast-feeding. These data suggest that the protective effects of human milk against otitis media may be due in part to inhibition of nasopharyngeal colonization with nontypeable H. influenzae by specific secretory IgA antibody. |
| Databáze: | OpenAIRE |
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