Critical regulatory levels in tumor differentiation: Signaling pathways, epigenetics and non-coding transcripts
| Autor: | Fatemeh Zolghadr, Babak Sarrafpour, Babak Bakhshinejad, Sapir Davuchbabny, Naisana Seyedasli |
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| Rok vydání: | 2021 |
| Předmět: |
Epigenomics
0303 health sciences Tumor differentiation Cancer Cell Differentiation Biology medicine.disease Phenotype General Biochemistry Genetics and Molecular Biology Metastasis Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Differentiation therapy Neoplasms Cancer cell medicine Cancer research Humans Epigenetics Signal transduction 030217 neurology & neurosurgery 030304 developmental biology Signal Transduction |
| Zdroj: | BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 43(5) |
| ISSN: | 1521-1878 |
| Popis: | Approaches to induce tumor differentiation often result in manageable and therapy-naive cellular states in cancer cells. This transformation is achieved by activating pathways that drive tumor cells away from plasticity, a state that commonly correlates with enhanced aggression, metastasis and resistance to therapy. Here, we discuss signaling pathways, epigenetics and non-coding RNAs as three main regulatory levels with the potential to drive tumor differentiation and hence as potential targets in differentiation therapy approaches. The success of an effective therapeutic regimen in one cancer, however, does not necessarily sustain across cancer types; a phenomenon largely resulting from heterogeneity in the genetic and physiological landscapes of tumor types necessitating an approach designed for each cancer's unique genetic and phenotypic build-up. |
| Databáze: | OpenAIRE |
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