Endometrial injury for RIF patients undergoing IVF/ICSI: a prospective nonrandomized controlled trial
Autor: | Nikolaos Papantoniou, Vasileios Pergialiotis, Maria Kreatsa, N Koutlaki, Charalampos Siristatidis, George Galazios |
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Rok vydání: | 2016 |
Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Pregnancy Rate Endocrinology Diabetes and Metabolism Fertilization in Vitro Hysteroscopy law.invention 03 medical and health sciences 0302 clinical medicine Endocrinology Ovulation Induction Randomized controlled trial Pregnancy law Humans Medicine Prospective Studies Sperm Injections Intracytoplasmic Birth Rate Gynecology 030219 obstetrics & reproductive medicine business.industry Obstetrics Obstetrics and Gynecology Ivf icsi Treatment Outcome 030104 developmental biology Female business Infertility Female Live Birth |
Zdroj: | Gynecological Endocrinology. 33:297-300 |
ISSN: | 1473-0766 0951-3590 |
DOI: | 10.1080/09513590.2016.1255325 |
Popis: | To evaluate the effect of endometrial injury on clinical outcomes in subfertile women with repeated implantation failures (RIF) undergoing assisted reproduction. In this prospective nonrandomized controlled trial, 103 subfertile women with RIF were included. Fifty-one underwent endometrial injury through hysteroscopy in the early follicular phase of the previous cycle and 52 underwent the standard protocol without any intervention. Live birth and miscarriage were the primary outcomes. Clinical and in vitro fertilization (IVF) cycle characteristics, were also compared between groups. Both groups were comparable in terms of baseline and cycle characteristics. Live birth rates were significantly higher in the study, compared with the control group (18/51 vs. 8/52, odds ratio (OR) = 0.25; 95% confidence interval (CI) = 0.10-0.64; p = 0.020), although miscarriage rates were similar (7/51 vs. 10/52, OR= 0.25; 95%CI= 0.12-0.66; p = 0.452). The rest of the outcomes parameters were comparable between groups. Logistic regression analysis revealed that endometrial injury and duration of subfertility were independent predictors of live birth after control of other variables (OR = 2.818; 95%CI = 1.044-7.605; p = 0.041 and OR = 0.674; 95%CI = 0.461-0.985, p = 0.042, respectively). Endometrial injury induced through office hysteroscopy in the preceding cycle in subfertile women with RIF improves live birth rates. |
Databáze: | OpenAIRE |
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