Central adrenal insufficiency: who, when, and how? From the evidence to the controversies – an exploratory review

Autor:	Luciani Carvalho, Isabela Biscotto, Rafael Batista, Mariana Rechia Bitencourt
Rok vydání:	2022
Předmět:	Hydrocortisone Endocrinology Diabetes and Metabolism Humans Glucocorticoids Biomarkers Adrenal Insufficiency
Zdroj:	Archives of Endocrinology and Metabolism.
ISSN:	2359-4292 2359-3997
Popis:	Central adrenal insufficiency (CAI) is a life-threatening disorder. This occurs when ACTH production is insufficient, leading to low cortisol levels. Since corticosteroids are crucial to many metabolic responses under organic stress and inflammatory conditions, CAI recognition and prompt treatment are vital. However, the diagnosis of CAI is challenging. This is not only because its clinical presentation is usually oligosymptomatic, but also because the CAI laboratory investigation presents many pitfalls. Thus, the clarification of when to use each test could be helpful in many contexts. The CAI challenge is also involved in treatment: Several formulations of synthetic steroids exist, followed by the lack of a biomarker for glucocorticoid replacement. This review aims to access all available literature to synthesize important topics about who should investigate CAI, when it should be suspected, and how CAI must be treated.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545202f97ca1d59377f285d2b73a1a96 https://doi.org/10.20945/2359-3997000000493 Zobrazit plný text záznamu