Author Correction: Pancreatic Ppy-expressing γ-cells display mixed phenotypic traits and the adaptive plasticity to engage insulin production
| Autor: | Eva Bru-Tari, Fabrizio Thorel, Valentina Cigliola, Marta Perez-Frances, Kenichiro Furuyama, Yoshio Fujitani, Daniel Oropeza, Maria Valentina Abate, Pedro Luis Herrera, Taïna Carreaux, Léon van Gurp |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Cell biology Science medicine.medical_treatment General Physics and Astronomy Mice Transgenic Biology Pancreatic Polypeptide General Biochemistry Genetics and Molecular Biology Islets of Langerhans Mice Pregnancy Insulin-Secreting Cells Diabetes mellitus medicine Animals Humans Insulin Cell Lineage Gene Knock-In Techniques RNA-Seq Protein Precursors Author Correction Pancreas Genetics Multidisciplinary Diabetes Body Weight General Chemistry Phenotypic trait Pancreatic Polypeptide-Secreting Cells medicine.disease Female Adaptive plasticity |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | The cellular identity of pancreatic polypeptide (Ppy)-expressing γ-cells, one of the rarest pancreatic islet cell-type, remains elusive. Within islets, glucagon and somatostatin, released respectively from α- and δ-cells, modulate the secretion of insulin by β-cells. Dysregulation of insulin production raises blood glucose levels, leading to diabetes onset. Here, we present the genetic signature of human and mouse γ-cells. Using different approaches, we identified a set of genes and pathways defining their functional identity. We found that the γ-cell population is heterogeneous, with subsets of cells producing another hormone in addition to Ppy. These bihormonal cells share identity markers typical of the other islet cell-types. In mice, Ppy gene inactivation or conditional γ-cell ablation did not alter glycemia nor body weight. Interestingly, upon β-cell injury induction, γ-cells exhibited gene expression changes and some of them engaged insulin production, like α- and δ-cells. In conclusion, we provide a comprehensive characterization of γ-cells and highlight their plasticity and therapeutic potential. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink