Liposome-bound cyclosporine: aqueous and vitreous level after subconjunctival injection
| Autor: | Steve Milner, Abdulrahman A. Alghadyan, Gholam A. Peyman, Kwan-Rong Liu, Bahram Khoobehi |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Time Factors genetic structures Vitreous Humors Cyclosporins High-performance liquid chromatography Injections Aqueous Humor polycyclic compounds medicine Animals Chromatography High Pressure Liquid Liposome Drug Carriers Chromatography Aqueous solution business.industry eye diseases Surgery Vitreous Body Ophthalmology Liposomes sense organs Rabbits Subconjunctival injection Drug carrier business Conjunctiva |
| Zdroj: | International ophthalmology. 12(2) |
| ISSN: | 0165-5701 |
| Popis: | The concentration of cyclosporine in the aqueous and vitreous humors of albino rabbits was measured, using HPLC at intervals of 24, 48, 96, and 192 hours after subconjunctival injections of 2.5 mg of free or liposome-bound cyclosporine. The aqueous concentration was reasonably high in both groups until day 4: 1050 nanograms per milliliter in the group receiving free cyclosporine, and 1438 nanograms per milliliter in the group receiving liposome-bound cyclosporine. The vitreous concentration was very low in both groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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