| Autor: |
Patricia Salvati, Giorgio Ukmar, Peter J. Schwartz, Carlo Patrono, Gaetano M. De Ferrari, Lorenzo Vaga, Mauro Grossoni |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Journal of the American College of Cardiology. 22(1):283-290 |
| ISSN: |
0735-1097 |
| DOI: |
10.1016/0735-1097(93)90845-r |
| Popis: |
Objectives. The goal of the present study was to evaluate the antifibrillatory and hemodynamic effects of pharmacologic muscarinic activation and to compare them with those of beta-adrenergic blockade. Background. Recent studies suggest a correlation between increased vagal activity and a reduced incidence of sudden cardiac death. Electrical stimulation of the vagus nerve reduces the incidence of ventricular fibrillation in a conscious animal model of sudden cardiac death. Methods. Eleven dogs with healed anterior myocardial infarction, in which a 2-min left circumflex coronary artery occlusion during exercise caused ventricular fibrillation, were studied. They underwent subsequent tests with saline solution, propranolol (1 mg/kg body weight), methacholine (0.5 μg/kg per min) and oxotremorine (8 μg/kg). Results. In the test with saline solution, 100% of the dogs developed ventricular fibrillation; this occurred in only 10% of the tests with propranolol (95% confidence interval 0.2% to 44%; p Conclusions. Propranolol was extremely effective against ventricular fibrillation. Methacholine and oxotremorine provided a significant, although less marked, protection and caused much less impairment of contractility compared with propranolol. Muscarinic receptor activation may represent a new approach to prevention of sudden cardiac death, particularly when beta-blockers are contraindicated and negative inotropic effects are to be avoided. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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