Nonparametric Linkage Analysis Between Schizophrenia and Candidate Genes of Dopaminergic and Serotonergic Systems
| Autor: | Carlos N. Pato, Alda M. Ambrósio, Michele T. Pato, Catarina R. Oliveira, Maria João Soares, James L. Kennedy, Isabel Coelho, Fabio Macciardi |
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| Rok vydání: | 2004 |
| Předmět: |
Genetics
Serotonin Candidate gene Chromosomes Human Pair 13 Genetic Linkage Dopamine DNA Mutational Analysis Dopaminergic Biology medicine.disease Serotonergic Statistics Nonparametric Psychiatry and Mental health Dopamine receptor Schizophrenia Genetic linkage medicine Humans Point Mutation Neurology (clinical) 5-HT receptor medicine.drug |
| Zdroj: | CNS Spectrums. 9:302-308 |
| ISSN: | 2165-6509 1092-8529 |
| DOI: | 10.1017/s109285290000924x |
| Popis: | Background:Alterations in dopaminergic and serotonergic systems have been implicated in the pathophysiology of schizophrenia for many years. This study was performed to assess the possible involvement of the dopamine receptor genes D2 (DRD2), D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A in the etiology of schizophrenia.Methods:We examined 33 multiplex schizophrenic families from Portugal.Results:Linkage analysis performed by GENE-HUNTER showed nonsignificant linkage for these genes. A maximum nonparametric linkage score of 1.635 (P=.032) at DRD2 gene was observed, and this finding suggests DRD2 gene for further studies.Conclusion:the polymorphisms studied at dopamine receptor genes D3, D4, serotonin receptor genes 1Dα, 1Dβ, and 2A do not have a major effect in susceptibility to schizophrenia in a Portuguese population. |
| Databáze: | OpenAIRE |
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