Combination of mural thrombus and age improves the identification of all-cause mortality following branched endovascular repair

Autor: Angela VandenHull, Ryan J. Patrick, Taylor N. Suess, Kelly Steffen, Valerie Bares, Stephen P. Gent, Katie Pohlson, Patrick W. Kelly
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Time Factors
Computed Tomography Angiography
Mural thrombus
Comorbidity
030204 cardiovascular system & hematology
Single Center
Logistic regression
Aortography
Risk Assessment
Article
03 medical and health sciences
Blood Vessel Prosthesis Implantation
0302 clinical medicine
Aneurysm
Predictive Value of Tests
Risk Factors
Internal medicine
medicine.artery
medicine
Humans
030212 general & internal medicine
cardiovascular diseases
Hospital Mortality
Prospective Studies
Mortality
Survival analysis
Aorta
Aged
Retrospective Studies
Aortic Aneurysm
Thoracic
business.industry
Mortality rate
Endovascular Procedures
Age Factors
Cardiac reserve
Thrombosis
Middle Aged
medicine.disease
Treatment Outcome
Cardiology
cardiovascular system
Surgery
Female
Cardiology and Cardiovascular Medicine
business
Zdroj: Journal of vascular surgery
ISSN: 1097-6809
0741-5214
Popis: Background: In-hospital and 30-day mortality rates of endovascular repair of thoracoabdominal aortic aneurysms shows a significant improvement over open surgery, although we are not seeing a significant difference at 1 year. We assess the hypothesis that a greater mural thrombus ratio within the aorta could function as an indicator of postoperative mortality. Methods: The mural thrombus ratio and preoperative comorbidities of 100 consecutive patients from a single center undergoing endo-debranching between 2012 and 2019 were evaluated. Logistic regression, survival analysis, and decision tree methods were used to examine each variable’s association with death at 1 year. Results: At the time of analysis, 73 subjects had 1-year outcomes and adequate imaging to assess the parameters. At 1 year, the overall survival for all subjects was 71.2% (21 died, 52 survived). For patients with a favorable mural thrombus ratio (n = 36), the overall 1-year survival was 86.1% (5 died, 31 survived). The subjects with an unfavorable mural thrombus ratio (n = 37), had an overall 1 year survival of 56.8% (16 died, and 21 survived). The only preoperative mortality factor that was statistically significant between the subjects with an unfavorable mural thrombus ratio was age of the patient. The survival for subjects 75 years and older with an unfavorable mural thrombus ratio was 90% (one died, nine survived) vs only 44.4% survival for subjects less than 75 years with an unfavorable mural thrombus ratio (15 died, 12 survived). Conclusions: This study examined whether a patient’s mural thrombus ratio may be an indicator of 1-year survival. These findings suggest that the combination of a patient’s aortic mural thrombus ratio and age can function as a preoperative indicator of their underlying cardiac reserve. Identifying patients with low cardiac reserve and fitness to handle the increased cardiac demands owing to the physiologic response to extensive aortic stent grafting before undergoing aortic repair may allow for modification of preoperative patient counseling and postoperative care guidelines to better treat this patient population.
Databáze: OpenAIRE
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