Standardization of FT4 and harmonization of TSH measurements: a request for input from endocrinologists and other physicians

Autor: Linda M. Thienpont, Graham Beastall, James D. Faix
Rok vydání: 2015
Předmět:
Male
Societies
Scientific
Risk analysis
0301 basic medicine
Pediatrics
medicine.medical_specialty
Standardization
Hormone Replacement Therapy
Consensus Development Conferences as Topic
Endocrinology
Diabetes and Metabolism
MEDLINE
Thyrotropin
030209 endocrinology & metabolism
Harmonization
Thyroid Function Tests
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Endocrinology
Physicians
Internal medicine
Internal Medicine
medicine
Humans
Medical physics
Hormone replacement therapy
Reference standards
Health Services Needs and Demand
business.industry
International Agencies
Reproducibility of Results
General Medicine
Reference Standards
Thyroid Diseases
Reference intervals
Thyroxine
030104 developmental biology
Chemistry
Clinical
030220 oncology & carcinogenesis
Practice Guidelines as Topic
Workforce
Female
business
Zdroj: Endocrine. 50:826-827
ISSN: 1559-0100
1355-008X
DOI: 10.1007/s12020-015-0752-1
Popis: Given the prevalence of thyroid disorders and the subtle signs and symptoms that may accompany subclinical disease, reliable laboratory testing for serum TSH and free thyroid hormones is important for both primary care physicians and endocrinologists. The laboratory community has recognized the need for standardization of thyroid function tests to achieve comparability of measurement results between methods. This applies in particular to tests for free T4 (FT4), which may be considered controversial in terms of clinical and analytical validity. However, variability is also observed with TSH testing - a fact which has not been emphasized in ongoing discussions regarding lowering the upper limit of normal and/or common decision limits to start treatment for hypothyroidism. In response to this need, the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee for Standardization of Thyroid Function Tests worked over the years towards the goal of standardization of FT4 and TSH testing.
Databáze: OpenAIRE
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