PLA2 polymorphism of platelet glycoprotein IIb/IIIa but not Factor V Leiden and prothrombin G20210A polymorphisms is associated with venous thromboembolism and more recurrent events in central Iran
| Autor: | Fatima Drees, Ali Mohammad Hasheminia, Hamid Rouhi Boroujeni, Batoul Pourgheysari |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Genotyping Techniques Population Platelet Glycoprotein GPIIb-IIIa Complex Iran Gastroenterology Polymerase Chain Reaction Pathogenesis Recurrence Internal medicine medicine Factor V Leiden Humans Thrombophilia education Genotyping Methylenetetrahydrofolate Reductase (NADPH2) education.field_of_study Polymorphism Genetic biology business.industry Factor V Hematology General Medicine Odds ratio Venous blood DNA Venous Thromboembolism Middle Aged medicine.disease Methylenetetrahydrofolate reductase biology.protein Prothrombin G20210A Female Prothrombin business Pulmonary Embolism Polymorphism Restriction Fragment Length |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 24(5) |
| ISSN: | 1473-5733 |
| Popis: | Inherited thrombophilic gene polymorphisms have been linked to the pathogenesis of venous thromboembolism (VTE). As there are very limited data of these polymorphisms in the Iranian population, we aimed to investigate the correlation between them and VTE in central Iran. Seventy-two unrelated VTE patients and 306 healthy control individuals were recruited for the study. Genotyping from venous blood with EDTA for the factor V Leiden (FVL), prothrombin (FII) G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T and PLA2 polymorphism of platelet glycoprotein IIb/IIIa were undertaken by PCR-restriction fragment length polymorphism (PCR-RFLP). A total of 57 investigated polymorphisms with a mean of 0.79 per individual and 151 with a mean of 0.49 were found in patients and controls, respectively (P |
| Databáze: | OpenAIRE |
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