Evidence that endogenous arginine-vasopressin (AVP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa
| Autor: | Gastone G. Nussdorfer, Giuseppina Mazzocchi, Anna Markowska, Francesco G. Musajo, Virgilio Meneghelli, Ludwik K. Malendowicz |
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| Rok vydání: | 1993 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Vasopressin medicine.drug_class Endocrinology Diabetes and Metabolism Clinical Biochemistry Neuropeptide Cell Count Cell Separation Biology Biochemistry chemistry.chemical_compound Endocrinology Adrenocorticotropic Hormone Zona fasciculata Corticosterone Internal medicine medicine Animals Deamino Arginine Vasopressin Rats Wistar Aldosterone Molecular Biology Cell Size urogenital system Adrenal cortex Angiotensin II Cell Biology Rats Arginine Vasopressin medicine.anatomical_structure nervous system chemistry Zona glomerulosa Potassium Molecular Medicine Corticosteroid Zona Glomerulosa hormones hormone substitutes and hormone antagonists |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 45:251-256 |
| ISSN: | 0960-0760 |
| DOI: | 10.1016/0960-0760(93)90339-x |
| Popis: | A 7-day subcutaneous infusion with the AVP antagonist [Deamino-Pen 1 , Val 4 , d -Arg 8 ]-vasopressin (AVP-A; 3 nmol·kg −1 ·min −1 ) significantly lowered plasma aldosterone concentration in rats, without affecting the plasma levels of ACTH and corticosterone. Prolonged AVP-A treatment caused a marked atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells, without inducing any significant change in zona fasciculata morphology. Isolated ZG cells from AVP-A-infused rats evidenced a notable decrease in both their basal and maximally-stimulated aldosterone production. The simultaneous infusion of rats with AVP (3 nmol·kg −1 ·min −1 ) completely reversed all these effects of AVP-A. These findings suggest that endogenous AVP may be specifically involved in the maintenance of the growth and steroidogenic capacity of rat adrenal ZG. Moreover, they seem to indicate that under basal conditions the pituitary-adrenal-glucocorticoid axis is independent of AVP release. |
| Databáze: | OpenAIRE |
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