In High-Risk Patients, Combination of Antiinflammatory Procedures During Cardiopulmonary Bypass Can Reduce Incidences of Inflammation and Oxidative Stress
| Autor: | Olivier Guillery, Magali Vernet, Stéphanie Lemaire-Ewing, Catherine Vergely, Andy Musat, Claude Girard, Luc Rochette, Jean-Jacques Goudeau, Michel Guiguet, Gaëlle Clermont |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Hemodynamics medicine.disease_cause law.invention Risk Factors law Hemofiltration Cardiopulmonary bypass medicine Humans Aprotinin Prospective Studies Coronary Artery Bypass Acute-Phase Reaction Prospective cohort study Aged Inflammation Pharmacology business.industry Incidence Intensive care unit Cardiac surgery Oxidative Stress surgical procedures operative Anesthesia Female Reactive Oxygen Species Cardiology and Cardiovascular Medicine business Oxidative stress medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 49:39-45 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0b013e31802c0cd0 |
| Popis: | Previous studies showed that cardiopulmonary bypass (CPB) was directly associated with a global activation of the inflammatory response, production of oxygen free radicals, and signs of myocardial injury. We therefore evaluated, in the weakest patients, the biological and clinical benefits of a therapeutic optimization of CPB through the combination of several antiinflammatory procedures. High-risk patients undergoing cardiac surgery under CPB were included in this prospective randomized study. Control patients (n = 14) underwent conventional CPB, and treated patients (n = 13) underwent a CPB with Baxter Duraflo II heparin-coated circuits, high doses of aprotinin, and pre-CPB hemofiltration. Usual clinical hemodynamic and biological criteria, inflammation, and oxidative stress markers were measured before, during, and to the second postoperative day. Free radicals were quantified using electronic spin resonance spectroscopy with a spin trap. Significantly lower concentrations of C-reactive protein, interleukin-6, creatine kinase-MB, I-troponin, lactic acid, and systemic free radicals were observed in the plasma of treated patients. These patients had a reduction of postoperative complications and of the length of stay in the intensive care unit. Therefore, pre-CPB therapeutic optimization can reduce the inflammatory response, lower the level of oxidative stress, and help to ameliorate clinical outcome in high-risk patients. |
| Databáze: | OpenAIRE |
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