Effects of Lean Beef Intake, as Part of a Healthful Dietary Pattern, on Cardiometabolic Risk Markers in Subjects at Risk for Diabetes Mellitus: a Controlled Feeding Trial (FS18-02-19)
| Autor: | Kevin C. Maki, Marjorie Bell, Cathleen E. Maki, Meredith L. Wilcox, Mary R. Dicklin, Orsolya M. Palacios |
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| Rok vydání: | 2019 |
| Předmět: |
Cardiometabolic risk
medicine.medical_specialty Nutrition and Dietetics biology business.industry C-reactive protein food and beverages Medicine (miscellaneous) Lipid metabolism Beef intake Dietary pattern medicine.disease Endocrinology medicine.anatomical_structure Internal medicine Diabetes mellitus biology.protein Medicine Obesity business Pancreas Homeostasis Food Science |
| Zdroj: | Current Developments in Nutrition. 3:nzz041.FS18-02 |
| ISSN: | 2475-2991 |
| DOI: | 10.1093/cdn/nzz041.fs18-02-19 |
| Popis: | OBJECTIVES: To assess and compare the effects of two diets low in saturated fatty acids (SFA): a United States Department of Agriculture (USDA) healthy US-style eating pattern (USDA diet) and a similar diet containing 150 g/d of lean beef in place of refined starches and added sugars (USDA-LB), on insulin sensitivity and other cardiometabolic markers in adults at-risk for type 2 diabetes (T2D). METHODS: This randomized, controlled crossover trial included two screening visits, a baseline visit, and two 28-d diet periods, separated by a 2-week washout. Thirty-three subjects (7 men, 26 women) provided evaluable data for this analysis. All foods were provided for each 28-d period. At baseline and at the end of each diet condition, insulin sensitivity and pancreatic beta-cell function were assessed with a 50-min intravenous glucose tolerance test. Other risk markers evaluated included fasting lipoprotein lipids, particles and subfractions, apolipoproteins A1 and B, homeostasis model assessment of fasting insulin sensitivity and beta-cell function, and high-sensitivity C-reactive protein. RESULTS: Baseline values and responses for selected variables are shown in the Table. Neither the USDA nor the USDA-LB diets had significant effects on insulin sensitivity or pancreatic beta-cell function; however, both produced a significant (P |
| Databáze: | OpenAIRE |
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