Coding of event nodes and narrative context in the hippocampus
| Autor: | Meryl Varadinov, Silvy H. P. Collin, Christian F. Doeller, Alejandro Vicente Grabovetsky, Branka Milivojevic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Neuroinformatics Adult Male Visual perception Brain activity and meditation Journal Club Memory Episodic Motion Pictures Brain mapping Hippocampus Language in Interaction 03 medical and health sciences Neural activity Young Adult 0302 clinical medicine Discrimination Psychological Image Processing Computer-Assisted Humans Narrative Episodic memory GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Cognitive science Communication Brain Mapping business.industry General Neuroscience Cognition Magnetic Resonance Imaging 030104 developmental biology Auditory Perception Visual Perception Female business Psychology 120 Memory and Space 030217 neurology & neurosurgery Psychomotor Performance Coding (social sciences) |
| Zdroj: | The Journal of Neuroscience The Journal of Neuroscience, 36, 12412-12424 The Journal of Neuroscience, 36, 49, pp. 12412-12424 |
| ISSN: | 0270-6474 |
| Popis: | Narratives may provide a general context, unrestricted by space and time, which can be used to organize episodic memories into networks of related events. However, it is not clear how narrative contexts are represented in the brain. Here we test the novel hypothesis that the formation of narrative-based contextual representations in humans relies on the same hippocampal mechanisms that enable formation of spatiotemporal contexts in rodents. Participants watched a movie consisting of two interleaved narratives while we monitored their brain activity using fMRI. We used representational similarity analysis, a type of multivariate pattern analysis, which uses across-voxel correlations as a proxy for neural-pattern similarity, to examine whether the patterns of neural activity can be used to differentiate between narratives and recurring narrative elements, such as people and locations. We demonstrate that the neural activity patterns in the hippocampus differentiate between event nodes (people and locations) and narratives (different stories) and that these narrative-context representations diverge gradually over time akin to remapping-induced spatial maps represented by rodent place cells.SIGNIFICANCE STATEMENTNarratives, especially in movie format, are very engaging and can be used to investigate neural mechanisms underlying cognitive functions in more naturalistic settings than that of traditional paradigms. Narratives also provide a more general context, unrestricted by space and time, that can be used to organize memories into networks of related events. For this reason, narratives are ideally suited to engage neural mechanisms underlying episodic memory formation. In this study, participants watched a movie with two interleaved narratives while their brain activity was monitored using fMRI. We show that the hippocampus, which is involved in formation of spatiotemporal contexts in episodic memory, also represents gradually diverging narrative contexts as well as narrative elements, such as people and locations. |
| Databáze: | OpenAIRE |
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