Risk factors for rectal colonization with vancomycin-resistant enterococci in Shiraz, Iran
| Autor: | Rahim Afkhamzadeh, Mehrdad Askarian, Florian Daxboeck, Ojan Assadian, Ahmad Monabbati |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Multivariate analysis Adolescent VRE medicine.medical_treatment Hospital Departments Iran Risk Factors Internal medicine Prevalence Medicine Humans Colonization Risk factor Child Rectal colonization Gram-Positive Bacterial Infections Aged Aged 80 and over Univariate analysis biology business.industry Infant Newborn Rectum Infant Vancomycin Resistance General Medicine biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses biology.organism_classification Surgery Anti-Bacterial Agents Carriage Infectious Diseases Logistic Models Enterococcus Case-Control Studies Child Preschool Vancomycin Female Hemodialysis business medicine.drug |
| Zdroj: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 12(2) |
| ISSN: | 1201-9712 |
| Popis: | Summary Objectives In order to determine the risk factors for rectal colonization with vancomycin-resistant enterococci (VRE) at the Shiraz Namazi Hospital, we performed a nested case–control study. Methods From December 2003 to July 2004 rectal swabs were taken from 700 randomly selected hospitalized patients every 5 days. Results A total of 99 of the 700 patients (14%) were colonized with VRE (cases) and 59 patients were colonized with vancomycin-sensitive strains (VSE), serving as controls. In the univariate analysis, history of antibiotic use ( p =0.04), underlying disease ( p =0.013), hemodialysis ( p =0.03), use of third generation cephalosporins ( p =0.04), use of vancomycin ( p =0.04), and duration of vancomycin therapy longer than 7 days ( p =0.02) were significantly associated with VRE colonization. In a multivariate analysis, underlying disease and the duration of vancomycin use longer than 7 days were independently associated with VRE colonization. Conclusion Our study, the first on VRE carriage in Iran, demonstrates that VRE prevalence is high in Shiraz and confirms earlier observations in other countries. The identified risk factor ‘use of vancomycin longer than 7 days' may be avoidable, indicating a feasible intervention strategy in the control of VRE. |
| Databáze: | OpenAIRE |
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