RETINAL PIGMENT EPITHELIUM UNDULATIONS IN ACUTE STAGE OF VOGT-KOYANAGI-HARADA DISEASE

Autor: Kouhei Hashizume, Shigeki Machida, Takamitsu Fujiwara, Daijiro Kurosaka, Yutaka Imamura, Masahiro Ishida
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Visual acuity
genetic structures
Visual Acuity
Administration
Oral
Retinal Pigment Epithelium
Betamethasone
0302 clinical medicine
Fluorescein Angiography
Infusions
Intravenous
medicine.diagnostic_test
Retinal detachment
Uveomeningoencephalitic Syndrome
General Medicine
Anatomy
Middle Aged
Fluorescein angiography
Drug Combinations
medicine.anatomical_structure
Acute Disease
Prednisolone
Female
medicine.symptom
Tomography
Optical Coherence
medicine.drug
Adult
Vogt–Koyanagi–Harada disease
medicine.medical_specialty
Methylprednisolone
03 medical and health sciences
Ophthalmology
medicine
Humans
Clinical significance
Glucocorticoids
Aged
Retinal pigment epithelium
business.industry
Retinal Detachment
medicine.disease
eye diseases
030104 developmental biology
030221 ophthalmology & optometry
sense organs
business
Biomarkers
Zdroj: Retina. 36:415-421
ISSN: 0275-004X
Popis: Purpose To determine the clinical significance of retinal pigment epithelium (RPE) undulations in the acute stage of Vogt-Koyanagi-Harada disease. Methods Retinal pigment epithelium undulations were detected and classified into 3 grades: Grade 1, slight; Grade 2, moderate; and Grade 3, severe undulations, in the enhanced depth imaging optical coherence tomographic images. The relationship between the clinical characteristics and the presence of RPE undulations was investigated. Results Among the 61 eyes of 31 patients with Vogt-Koyanagi-Harada disease, 40 eyes had some degree of RPE undulations (Grade 1 = 12, Grade 2 = 15, and Grade 3 = 13). The patients with RPE undulations in both eyes were significantly older at the onset (P = 0.0002). The eyes with RPE undulations were more likely to develop posterior recurrences (P = 0.032) and have worse vision at 12 months (P = 0.043). Multiple regression analysis revealed that RPE undulations were an independent predictor of posterior recurrences (P = 0.009) and poor visual outcomes (P = 0.035). Conclusion Retinal pigment epithelium undulations detected by enhanced depth imaging optical coherence tomographic are relatively frequent occurrences at the acute stage of Vogt-Koyanagi-Harada, and their presence is a predictor of posterior recurrences and poor visual outcomes after high-dose steroid therapy.
Databáze: OpenAIRE
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