Exercise for cardiac health and regeneration: killing two birds with one stone
| Autor: | Cristiane Matsuura, Juliana Pereira Borges, Karine S. Verdoorn |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty microRNA business.industry Disease outcome Cardiovascular health General Medicine Stimulus (physiology) Bioinformatics Cardiac growth 03 medical and health sciences 030104 developmental biology Physical medicine and rehabilitation Editorial Medicine business Exercise Research Paper |
| Zdroj: | Theranostics |
| ISSN: | 2305-5839 |
| Popis: | Limited microRNAs (miRNAs, miRs) have been reported to be necessary for exercise-induced cardiac growth and essential for protection against pathological cardiac remodeling. Here we determined members of the miR-17-92 cluster and their passenger miRNAs expressions in two distinct murine exercise models and found that miR-17-3p was increased in both. miR-17-3p promoted cardiomyocyte hypertrophy, proliferation, and survival. TIMP-3 was identified as a direct target gene of miR-17-3p whereas PTEN was indirectly inhibited by miR-17-3p. Inhibition of miR-17-3p in vivo attenuated exercise-induced cardiac growth including cardiomyocyte hypertrophy and expression of markers of myocyte proliferation. Importantly, mice injected with miR-17-3p agomir were protected from adverse remodeling after cardiac ischemia/reperfusion injury. Collectively, these data suggest that miR-17-3p contributes to exercise-induced cardiac growth and protects against adverse ventricular remodeling. miR-17-3p may represent a novel therapeutic target to promote functional recovery after cardiac ischemia/reperfusion. |
| Databáze: | OpenAIRE |
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