Involvement of the Calcium-sensing Receptor in Human Taste Perception
| Autor: | Naohiro Miyamura, Takeaki Ohsu, Sen Takeshita, Tomohiko Yamanaka, Hiroaki Nagasaki, Yuzuru Eto, Toshihiro Hatanaka, Yusuke Amino, Yutaka Maruyama |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Agonist medicine.medical_specialty Taste medicine.drug_class Sensory system Umami Naphthalenes Biology Biochemistry Cell Line Receptors G-Protein-Coupled Xenopus laevis Japan Internal medicine medicine Animals Humans Histidine Protamines Mode of action Receptor Molecular Biology Mechanisms of Signal Transduction Heparin Antagonists Taste Perception Cell Biology Endocrinology TAS2R38 Calcium Female Cinacalcet Calcium-sensing receptor Oligopeptides Receptors Calcium-Sensing |
| Zdroj: | Journal of Biological Chemistry. 285:1016-1022 |
| ISSN: | 0021-9258 |
| Popis: | By human sensory analyses, we found that various extracellular calcium-sensing receptor (CaSR) agonists enhance sweet, salty, and umami tastes, although they have no taste themselves. These characteristics are known as "kokumi taste" and often appear in traditional Japanese cuisine. Although GSH is a typical kokumi taste substance (taste enhancer), its mode of action is poorly understood. Here, we demonstrate how the kokumi taste is enhanced by the CaSR, a close relative of the class C G-protein-coupled receptors T1R1, T1R2, and T1R3 (sweet and umami receptors). We identified a large number of CaSR agonist gamma-glutamyl peptides, including GSH (gamma-Glu-Cys-Gly) and gamma-Glu-Val-Gly, and showed that these peptides elicit the kokumi taste. Further analyses revealed that some known CaSR agonists such as Ca(2+), protamine, polylysine, L-histidine, and cinacalcet (a calcium-mimetic drug) also elicit the kokumi taste and that the CaSR-specific antagonist, NPS-2143, significantly suppresses the kokumi taste. This is the first report indicating a distinct function of the CaSR in human taste perception. |
| Databáze: | OpenAIRE |
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