The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development
Autor: | Masato Fujioka, Hideyuki Okano, Kaoru Ogawa, Ayako Y. Murayama, Makoto Hosoya |
---|---|
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
inner ear Organogenesis cochlea Peripherins Congenital hearing loss primate Biochemistry Regenerative medicine common marmoset Mice 0302 clinical medicine Tubulin Primate Conserved Sequence New World monkey biology Marmoset Gene Expression Regulation Developmental Callithrix Transcription Factor Brn-3C medicine.anatomical_structure Parvalbumins Calbindin 1 Sulfate Transporters 030220 oncology & carcinogenesis Myosin VIIa Models Animal Original Article Cyclin-Dependent Kinase Inhibitor p27 LIM-Homeodomain Proteins GATA3 Transcription Factor 03 medical and health sciences Species Specificity biology.animal medicine otorhinolaryngologic diseases Animals Humans Inner ear Molecular Biology Cochlea Aquaporin 4 SOXB1 Transcription Factors Cell Biology Original Articles biology.organism_classification Embryo Mammalian 030104 developmental biology Neuroscience |
Zdroj: | The Febs Journal |
ISSN: | 1742-4658 |
Popis: | Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate‐specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development. We investigated cochlear development in a small New World monkey species, the common marmoset (Callithrix jacchus). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development. |
Databáze: | OpenAIRE |
Externí odkaz: |