The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development

Autor: Masato Fujioka, Hideyuki Okano, Kaoru Ogawa, Ayako Y. Murayama, Makoto Hosoya
Rok vydání: 2019
Předmět:
0301 basic medicine
inner ear
Organogenesis
cochlea
Peripherins
Congenital hearing loss
primate
Biochemistry
Regenerative medicine
common marmoset
Mice
0302 clinical medicine
Tubulin
Primate
Conserved Sequence
New World monkey
biology
Marmoset
Gene Expression Regulation
Developmental
Callithrix
Transcription Factor Brn-3C
medicine.anatomical_structure
Parvalbumins
Calbindin 1
Sulfate Transporters
030220 oncology & carcinogenesis
Myosin VIIa
Models
Animal
Original Article
Cyclin-Dependent Kinase Inhibitor p27
LIM-Homeodomain Proteins
GATA3 Transcription Factor
03 medical and health sciences
Species Specificity
biology.animal
medicine
otorhinolaryngologic diseases
Animals
Humans
Inner ear
Molecular Biology
Cochlea
Aquaporin 4
SOXB1 Transcription Factors
Cell Biology
Original Articles
biology.organism_classification
Embryo
Mammalian
030104 developmental biology
Neuroscience
Zdroj: The Febs Journal
ISSN: 1742-4658
Popis: Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate‐specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
We investigated cochlear development in a small New World monkey species, the common marmoset (Callithrix jacchus). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
Databáze: OpenAIRE
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