Quality of Life and Adverse Effects of Olanzapine Versus Risperidone Therapy in Patients with Schizophrenia
| Autor: | Raimundo Fernandes de Araújo Júnior, Luiz Alberto Lira Soares, Vanessa de Paula Soares Rachetti, Susana Barbosa Ribeiro, Katarina Melo Chaves, Antônio Filgueira Júnior, Gerlane Coelho Bernardo Guerra, Aurigena Antunes de Araújo, Maria do Socorro Costa Feitosa Alves, Antoni Serrano-Blanco |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Employment Male Quality of life Olanzapine medicine.medical_specialty Galactorrhea Drug-Related Side Effects and Adverse Reactions Side effect medicine.drug_class Atypical antipsychotic Benzodiazepines Internal medicine Activities of Daily Living Ambulatory Care medicine Humans Interpersonal Relations Psychiatry Adverse effect Risperidone business.industry Social Participation medicine.disease Psychiatry and Mental health Cross-Sectional Studies Schizophrenia Quality of Life Female medicine.symptom business Brazil Antipsychotic Agents medicine.drug |
| Zdroj: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
| ISSN: | 1573-6709 0033-2720 |
| DOI: | 10.1007/s11126-012-9233-3 |
| Popis: | This cross-sectional study aimed to compare the effects of treatment with an atypical antipsychotic drug (olanzapine or risperidone) on quality of life (QoL) and to document adverse effects in 115 patients diagnosed with schizophrenia who attended the ambulatory service of Hospital Dr. João Machado, Natal, Rio Grande do Norte, Brazil. Socioeconomic, sociodemographic, and clinical variables were compared. The QoL Scale validated for Brazil (QLS-BR) was used to evaluate QoL, and adverse effects were assessed using the Udvalg for Kliniske Undersøgelser Side Effect Rating Scale. Data were analyzed using the χ(2) test and Student's t test, with a significance level of 5 %. Patients in both drug groups showed severe impairment in the occupational domain of the QLS-BR. Global QLS-BR scores indicated impairment among risperidone users and severe impairment among olanzapine users. The most significant side effects were associated with risperidone, including asthenia/lassitude/fatigue, somnolence/sedation, paresthesia, change in visual accommodation, increased salivation, diarrhea, orthostatic posture, palpitations/tachycardia, erythema, photosensitivity, weight loss, galactorrhea, decreased sexual desire, erectile/orgasmic dysfunction, vaginal dryness, headache, and physical dependence. QoL was impaired in patients using olanzapine and in those using risperidone. Risperidone use was associated with psychic, neurological, and autonomous adverse effects and other side effects. |
| Databáze: | OpenAIRE |
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