Effect of Continuous Irradiation with a Very Low Dose of Gamma Rays on Life Span and the Immune System in SJL Mice Prone to B-Cell Lymphoma
| Autor: | M. Courtade-Saïdi, S. Jozan, V. Cances-Lauwers, L. Lacoste-Collin, G. Gasset, B. Pipy, C. Caratero |
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| Rok vydání: | 2007 |
| Předmět: |
Pathology
medicine.medical_specialty Lymphoma B-Cell Time Factors Biophysics Spleen Biology Ionizing radiation Mice Immune system medicine Animals Radiology Nuclear Medicine and imaging B-cell lymphoma Cells Cultured Carcinogen Radiation Body Weight Dose-Response Relationship Radiation Cytotoxicity Tests Immunologic medicine.disease Coculture Techniques Lymphoma Killer Cells Natural Survival Rate medicine.anatomical_structure Gamma Rays Immune System Cancer research Female Lymph CD8 |
| Zdroj: | Radiation Research. 168:725-732 |
| ISSN: | 1938-5404 0033-7587 |
| DOI: | 10.1667/rr1007.1 |
| Popis: | Ionizing radiation has been shown to have dose- and dose-rate-dependent carcinogenic effects on the hematopoietic and lymphoreticular systems. We report here that continuous exposure to a low dose of gamma rays influences the course of spontaneous B-cell lymphoma in SJL mice. We studied the biological effects of 10 cGy year(-1) gamma rays on the life span of 560 4-week-old SJL/J female mice and on various parameters of the cell-mediated immune response. Life span was slightly prolonged. The mean survival was 397 days for controls and 417 days for irradiated mice that died with lymphoma (P = 0.34). In lymph nodes and spleen, lower percentages of CD4+ and CD8+ T cells were observed in irradiated mice before 32 weeks. Interestingly, the percentages of CD49+ NK cells were increased in the spleens of irradiated mice at 28 weeks (0.61 +/- 0.08% compared to 0.43 +/- 0.12% in controls, P = 0.01) and at 32 weeks (0.62 +/- 0.24% compared to 0.33 +/- 0.09%, P = 0.02), while NK cell activity remained unchanged in exposed mice. These results provide further support for the absence of harmful effects of a continuous very low dose of radiation on life span and incidence of lymphoma in SJL mice. |
| Databáze: | OpenAIRE |
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