Genetic etiology of cleft lip and cleft palate
| Autor: | CS Prashanth, N Srinath, AN Mahamad Irfanulla Khan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
cleft palate
Candidate gene medicine.medical_specialty genome-wide association study business.industry Genome-wide association study cleft lip Bioinformatics mutations Genetic etiology Epidemiology Etiology Medicine molecular biology genetics Craniofacial business candidate genes lcsh:Science (General) Psychosocial lcsh:Q1-390 |
| Zdroj: | AIMS Molecular Science, Vol 7, Iss 4, Pp 328-348 (2020) |
| ISSN: | 2372-0301 |
| Popis: | Genetic studies in humans have demonstrated that Cleft lip with or without cleft palate (CL/P) have a diverse genetic background and probably environmental factors influencing these malformations. CL/P is one of the most common congenital birth defects in the craniofacial region with complex etiology involving multiple genetic factors, environmental factors and gene-environment interaction. Children born with these defects suffer from various difficulties such as difficulty in speech, hearing, feeding and other psychosocial problems, and their rehabilitation involves a multidisciplinary approach. The article describes the brief introduction of CL/P, epidemiology and general concepts, etiological factors, and the genes implicated in the etiology of nonsyndromic CL/P (NSCL/P) as suggested by different human genetic studies, animal models, and other expression studies. |
| Databáze: | OpenAIRE |
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