Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia

Autor:	Ik Jun Moon, Hae Kyeong Yoon, Doyeun Kim, Myung Eun Choi, Seung Hee Han, June Hyun Park, Sun Woo Hong, Hyesoo Cho, Dong-Ki Lee, Chong Hyun Won
Rok vydání:	2022
Předmět:	Mice Disease Models Animal Receptors Androgen Drug Discovery Animals Humans Pharmaceutical Science Molecular Medicine Alopecia RNA Messenger RNA Small Interfering Hair Follicle Hair
Zdroj:	Molecular Pharmaceutics. 20:128-135
ISSN:	1543-8392 1543-8384
DOI:	10.1021/acs.molpharmaceut.2c00510
Popis:	Asymmetric small interfering RNAs (asiRNAs) that mediate RNA interference have been investigated for therapeutic use in various tissues, including skin tissue. Androgenetic alopecia (AGA) is caused by a combination of genetic factors, resulting in sensitivity to dihydrotestosterone (DHT), which binds to the androgen receptor (AR) to mediate a series of biomolecular changes leading to hair loss. This study aimed to evaluate the therapeutic potential of a cell-penetrating, AR-targeting asiRNA (cp-asiAR) for AGA treatment, which was designed to silence the
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::543bcce5d4ddac8b0f12a63ab8ad98a9 https://doi.org/10.1021/acs.molpharmaceut.2c00510 Zobrazit plný text záznamu