Surgical resection and survival outcomes in metastatic young adult colorectal cancer patients
| Autor: | Kristen K. Ciombor, Lea Matsuoka, Christina E. Bailey, Nina D. Arhin, Arvind Dasari, Alexander T. Hawkins, Cody M. Lebeck Lee, Andreana N. Holowatyj, Timothy M. Geiger, Marc T. Roth, Michael B. Hopkins, Michael Lapelusa, Chan Shen, Audrey E. Kam, Cathy Eng |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Oncology Adult Male Cancer Research medicine.medical_specialty Time Factors Colorectal cancer overall survival Kaplan-Meier Estimate surgery 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans cancer Radiology Nuclear Medicine and imaging Young adult RC254-282 Original Research Proportional Hazards Models colorectal Proportional hazards model business.industry Incidence (epidemiology) Incidence Palliative Care Metastasectomy Cancer Clinical Cancer Research Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Primary tumor Log-rank test 030104 developmental biology 030220 oncology & carcinogenesis young adult Female business Colorectal Neoplasms SEER Program |
| Zdroj: | Cancer Medicine, Vol 10, Iss 13, Pp 4269-4281 (2021) Cancer Medicine |
| ISSN: | 2045-7634 |
| Popis: | Background The incidence of colorectal cancer in adults younger than age 50 has increased with rates expected to continue to increase over the next decade. The objective of this study is to examine the survival benefit of surgical resection (primary and/or metastatic) versus palliative therapy in this patient population. Methods We identified 6708 young adults aged 18–45 years diagnosed with metastatic colorectal cancer (mCRC) from 2004 to 2015 from the SEER database. Overall survival (OS) was analyzed using Kaplan–Meier estimation, log rank test, and multivariate Cox proportional hazards model. Results Sixty‐three percent of patients in our study underwent primary tumor resection (PTR), with 40% undergoing PTR alone and 23% undergoing both resection of primary disease and metastasectomy. The median OS for patients who underwent both PTR and metastasectomy was 36 months, compared to 13 months for those who did not receive any surgical intervention. The multivariate analysis showed significant OS benefit of receiving both PTR and metastasectomy (HR 0.34, 95% CI: 0.31–0.37, p The incidence of colorectal cancer in adults younger than age 50 has increased with rates expected to continue to increase over the next decade. The objective of this study is to examine the survival benefit of surgical resection (primary and/or metastatic) vs palliative therapy in this patient population. Our study provides evidence of statistically significant increase in OS for young mCRC patients who undergo surgical intervention of the primary and/or metastatic site. |
| Databáze: | OpenAIRE |
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