Morphological Evaluation of the Tissue Reaction to Subcutaneous Implantation of Decellularized Matrices
| Autor: | E. A. Gubareva, I. S. Gumenyuk, R. Z. Nakokhov, E. V. Kuevda, A. S. Sotnichenko |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Molecular composition T-Lymphocytes Lymphocyte Diaphragm Receptors Cell Surface 02 engineering and technology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Tissue engineering Antigen Antigens CD medicine Animals Transplantation Homologous Macrophage Lectins C-Type Rats Wistar Lung Skin B-Lymphocytes Deoxyribonucleases Decellularization Tissue Engineering Tissue Scaffolds Chemistry Macrophages Heart General Medicine 021001 nanoscience & nanotechnology Extracellular Matrix Rats Mannose-Binding Lectins 030104 developmental biology medicine.anatomical_structure Morphological analysis Subcutaneous implantation 0210 nano-technology Biomarkers Mannose Receptor Deoxycholic Acid |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:287-292 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Based on the data of morphological analysis, we performed histological evaluation of rat tissue reaction to subcutaneous implantation of decellularized matrices of intrathoracic organs and tissues. Cell composition of the inflammatory infiltrate was analyzed, and the dynamics of macrophage and T and B lymphocyte content was assessed on days 7 and 14 of the experiment. It was found that the reaction to implantation depended not only on the quality of decellularization and efficiency of removal of antigen molecules, but also on the original histological structure and quality of preimplantation processing of the transplant. |
| Databáze: | OpenAIRE |
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