Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes
| Autor: | Peyton Jacob, Neal L. Benowitz, Delia A. Dempsey, Gideon St.Helen, Christopher Havel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Nicotine
genetic structures Electronic Nicotine Delivery Systems Pharmacology Toxicology Medical and Health Sciences Article E-cigarette pharmacology 03 medical and health sciences 0302 clinical medicine Flavors Heart Rate medicine Humans Pharmacology (medical) 030212 general & internal medicine Cross-Over Studies business.industry Psychology and Cognitive Sciences Substance Abuse food and beverages Tobacco Products equipment and supplies Flavoring Agents E-cigarettes Psychiatry and Mental health Nicotine delivery Nicotine pharmacokinetics Taste business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | St Helen, Gideon; Dempsey, Delia A; Havel, Christopher M; Jacob, Peyton; & Benowitz, Neal L. (2017). Impact of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes.. Drug and alcohol dependence, 178, 391-398. doi: 10.1016/j.drugalcdep.2017.05.042. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/1dt1p2dt |
| ISSN: | 0376-8716 |
| Popis: | To describe the effect of e-liquid flavors on nicotine intake and pharmacology of e-cigarettes.11 males and 3 females participated in a 3-day inpatient crossover study with strawberry, tobacco, and their usual flavor e-liquid. Nicotine levels were nominally 18mg/mL in the strawberry (pH 8.29) and tobacco (pH 9.10) e-liquids and ranged between 3-18mg/mL in the usual brands (mean pH 6.80). Each day consisted of a 15-puff session followed by 4h of abstinence, then 90min of ad libitum use. Subjects used a KangerTech mini ProTank 3.After 15 puffs, the amount of nicotine inhaled and systemically retained were not significantly different between the strawberry and tobacco e-liquids but plasma AUC(0→180) was significantly higher with the strawberry e-liquid. While not significantly different, Cmax was 22% higher and various early time point AUCs to measure rate of rise of nicotine in blood ranged between 17 and 23% higher with the strawberry e-liquid compared to the tobacco e-liquid. During ad libitum use, systemic exposure to nicotine (AUC(0→90)) was the same for the tobacco and usual brand e-liquids but were both significantly lower than after using the strawberry e-liquid. The usual flavors were more liked and satisfying than the strawberry and tobacco e-liquids.Flavors influence nicotine exposure through flavor liking, may affect rate of nicotine absorption possibly through pH effects, and contribute to heart rate acceleration and subjective effects of e-cigarettes. E-cigarette users titrate their nicotine exposure but the extent of titration may vary across flavors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect