Axon Regeneration Requires a Conserved MAP Kinase Pathway
| Autor: | Erik M. Jorgensen, Michael Bastiani, Paola Nix, Linda Hauth, Marc Hammarlund |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Aging
MAP Kinase Kinase 4 MAP Kinase Signaling System medicine.medical_treatment Growth Cones Models Biological Article medicine Animals Axon Caenorhabditis elegans Caenorhabditis elegans Proteins Growth cone gamma-Aminobutyric Acid Motor Neurons Multidisciplinary MAP kinase kinase kinase biology Regeneration (biology) Axotomy Motor neuron MAP Kinase Kinase Kinases Axons Nerve Regeneration Cell biology medicine.anatomical_structure nervous system Mitogen-activated protein kinase Mutation biology.protein RNA Interference Neuron Mitogen-Activated Protein Kinases |
| Zdroj: | Science. 323:802-806 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Regeneration of injured neurons can restore function, but most neurons regenerate poorly or not at all. The failure to regenerate in some cases is due to a lack of activation of cell-intrinsic regeneration pathways. These pathways might be targeted for the development of therapies that can restore neuron function after injury or disease. Here, we show that the DLK-1 mitogen-activated protein (MAP) kinase pathway is essential for regeneration in Caenorhabditis elegans motor neurons. Loss of this pathway eliminates regeneration, whereas activating it improves regeneration. Further, these proteins also regulate the later step of growth cone migration. We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth. |
| Databáze: | OpenAIRE |
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