Targeted nanocarriers based on iodinated-cyanine dyes as immunomodulators for synergistic phototherapy
| Autor: | Caiyun Ma, Wei Zhu, Shangcong Han, Zijun Shen, Yan Liang, Qingming Ma, Jie Cao, Jinnan Chi, Yong Sun |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Programmed cell death
medicine.medical_treatment Apoptosis Photodynamic therapy 02 engineering and technology Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system In vivo Cell Line Tumor medicine Animals Humans Immunologic Factors General Materials Science Hydrocarbons Iodinated chemistry.chemical_classification Drug Carriers Mice Inbred BALB C Reactive oxygen species Singlet oxygen food and beverages Neoplasms Experimental Carbocyanines 021001 nanoscience & nanotechnology Nanostructures RAW 264.7 Cells Photochemotherapy chemistry 030220 oncology & carcinogenesis Cancer research Female Nanocarriers 0210 nano-technology |
| Zdroj: | Nanoscale. 12:11008-11025 |
| ISSN: | 2040-3372 2040-3364 |
| DOI: | 10.1039/c9nr10674j |
| Popis: | Photodynamic therapy (PDT), as one of the most powerful photo-therapeutic strategies for cancer treatment with minimum invasiveness, can effectively damage local tumor cells and significantly induce systemic antitumor immunity. However, current nanotechnology-assisted PDT-immunomodulators have either poor penetration for deep tumors or low singlet oxygen generation. Herein, we construct a novel theranostic nanocarrier (HA-PEG-CyI, HPC) by inducing the self-assembly of PEGylated CyI and attaching the ligand HA to its surface. The prepared HPC can be used as an ideal PDT-immunomodulator for synergistic cancer therapy. CyI is an iodinated-cyanine dye with enhanced singlet oxygen generation ability as well as excellent photo-to-photothermal and near-infrared fluorescence imaging properties. Under 808 nm laser irradiation, the prepared HPC can generate both reactive oxygen species (ROS) and elevate temperature which can subsequently result in apoptosis and necrosis at tumor sites. Moreover, the HPC-induced cell death can generate a series of acute inflammatory reactions, leading to systemic immunity induction and secondary death of tumor cells, which further results in reducing tumor recurrence. In vitro and in vivo results show that HPC can enhance the tumor targeting efficacy, generate ROS efficiently and exhibit a high temperature response under NIR irradiation, which working together can activate immune responses for synergistic phototherapy on tumor cells. Accordingly, the proposed multi-functional HPC nanocarriers represent an important advance in PDT and can be used as a superior cancer treatment strategy with great promise for clinical applications. |
| Databáze: | OpenAIRE |
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