PEG-hirudin/iloprost Coating of Small Diameter ePTFE Grafts Effectively Prevents Pseudointima and Intimal Hyperplasia Development
| Autor: | J. Schmidt, Christoph Heidenhain, Peter Neuhaus, Gerhard Schmidmaier, M. Heise, U. Settmacher, I. Husmann |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Hirudin
medicine.medical_specialty Intimal hyperplasia Polyesters Sus scrofa Polyethylene glycol Anastomosis chemistry.chemical_compound Coated Materials Biocompatible Fibrinolytic Agents PEG ratio medicine Animals Popliteal Artery Iloprost Polytetrafluoroethylene Vascular Patency Medicine(all) Hyperplasia business.industry Anastomosis Surgical Heparin Hirudins medicine.disease Thrombosis Blood Vessel Prosthesis Surgery Femoral Artery surgical procedures operative chemistry Antithrombotic coating Tunica Intima Peripheral grafts business Cardiology and Cardiovascular Medicine Blood Flow Velocity medicine.drug |
| Zdroj: | Journal of Vascular Surgery. 44(4) |
| ISSN: | 0741-5214 |
| DOI: | 10.1016/j.jvs.2006.08.044 |
| Popis: | ObjectivesSmall diameter PTFE grafts are prone to thrombosis and intimal hyperplasia development. Heparin graft coating has beneficial effects but also potential drawbacks. The purpose of this study was to evaluate the experimental efficacy of PEG-hirudin/iloprost coated small caliber PTFE grafts.MethodsThirty-six femoro-popliteal ePTFE grafts (expanded polytetrafluoroethylene, diameter 4 mm) were inserted into 18 pigs. Grafts were randomised individually for each leg and grouped for 3 groups. Group I consisted of native ePTFE grafts, group II were grafts coated with a polylactide polymer (PLA) without drugs and group III grafts were coated with PLA containing a polyethylene glycol (PEG)-hirudin/iloprost combination. The follow-up period was 6 weeks. Patency rates were calculated and development of pseudointima inside the grafts was noted. Thickness of intimal hyperplasia at the distal anastomoses was measured using light microscopy.ResultsPatency rates for group I were 6/9 (67%), for group II 9/10 (90%) and 12/12 (100%) for group III. In groups I and II there was a significant reduction of blood flow proximal to the graft at graft harvest, to 29±12 and 28±20ml/min respectively (both p |
| Databáze: | OpenAIRE |
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