Astragaloside attenuates myocardial injury in a rat model of acute myocardial infarction by upregulating hypoxia inducible factor-1α and Notch1/Jagged1 signaling
| Autor: | Xiao-Bo Zhang, Jun-Min Yu, Yina Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Cardiotonic Agents hypoxia inducible factor 1 α Myocardial Infarction 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Astragaloside Internal medicine Genetics medicine Animals myocardial injury Myocardial infarction Receptor Notch1 Receptor Molecular Biology Notch1 Oncogene business.industry Myocardium Articles Saponins Hypoxia (medical) Hypoxia-Inducible Factor 1 alpha Subunit medicine.disease Rats Disease Models Animal medicine.anatomical_structure Endocrinology Jagged1 Gene Expression Regulation Oncology chemistry Apoptosis Ventricle 030220 oncology & carcinogenesis Molecular Medicine medicine.symptom Ligation business Jagged-1 Protein Signal Transduction |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| DOI: | 10.3892/mmr.2017.6522 |
| Popis: | The present study aimed to investigate the mechanisms underlying the cardioprotective effect of Astragaloside against myocardial injury following myocardial infarction (MI) in a rat model. Male Wistar rats were subjected to left anterior descending branch ligation. The rats that survived 24 h (n=18) were randomly and equally assigned to three groups: MI model group, and 2.5 and 10 mg/kg/day Astragaloside group. A further six rats underwent identical surgical procedures without artery ligation, serving as sham controls. Following 28 days of treatment, the left ventricle was harvested for morphological analysis, and mRNA and protein expression levels of hypoxia inducible factor-1α (HIF-1α), Notch1 and Jagged1 were measured. Treatment with Astragaloside attenuated pathological changes in the myocardium. Compared with untreated MI rats, rats treated with Astragaloside exhibited significantly increased mRNA expression levels of HIF-1α, Notch1 and Jagged1 (all P |
| Databáze: | OpenAIRE |
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