Latent toxoplasmosis and vitamin D concentration in humans: three observational studies
| Autor: | Sarka Kankova, Dobroslava Jandová, Ludmila Máčová, Katerina Sykorova, Marie Bičíková, Jaroslav Flegr, Jana Hlaváčová |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 030231 tropical medicine Physiology vitamin D deficiency 030308 mycology & parasitology 03 medical and health sciences 0302 clinical medicine Vitamin B Deficiency Diabetes mellitus parasitic diseases Vitamin D and neurology medicine Humans Vitamin D Depression (differential diagnoses) Calcifediol 0303 health sciences biology Mental Disorders Toxoplasma gondii Cancer Middle Aged biology.organism_classification medicine.disease Toxoplasmosis Cross-Sectional Studies Schizophrenia Case-Control Studies Latent Infection Parasitology Female Toxoplasma |
| Zdroj: | Folia parasitologica. 68 |
| ISSN: | 1803-6465 |
| Popis: | Numerous recent studies show that vitamin D deficiency potentiates various chronic physical and psychiatric disorders and diseases. It has been shown that a similar range of disorders is also associated with latent infection with Toxoplasma gondii (Nicolle et Manceaux, 1908). For instance, among cancer, diabetes and schizophrenia patients, we find a higher prevalence of both toxoplasmosis and vitamin D deficiency. Theoretically, therefore, vitamin D deficiency could be the missing link between toxoplasmosis and these disorders. We tested this hypothesis by searching for decreased vitamin D levels in the serum of subjects infected with T. gondii (furthermore called Toxoplasma-infected subjects) in two cross-sectional and one case-control study. Results of the first cross-sectional study (N = 72) suggest that Toxoplasma-infected neurasthenic patients have non-significantly lower levels of calcidiol than Toxoplasma-free patients (study A: P = 0.26 in women, P = 0.68 in men). However, two other studies (study B: N = 400; study C: N = 191) showed a non-significantly higher concentration of vitamin D in Toxoplasma-infected subjects than in Toxoplasma-free subjects both in men (study B: P = 0.70, study C: P = 0.55) and in women (study B: P = 0.64, study C: P = 0.12). Taken together, our preliminary results thus do not support the hypothesis that toxoplasmosis could be associated with vitamin D decrease. |
| Databáze: | OpenAIRE |
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