The Chemical Likelihood of Ribonucleotide-α-Amino acid Copolymers as Players for Early Stages of Evolution
| Autor: | Ziwei Liu, Ghinwa Ajram, Robert Pascal, Jean-Christophe Rossi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Translation Ribonucleotide Polymers Stereochemistry Aminoacylation Phosphoramidate Biology 010603 evolutionary biology 01 natural sciences Polymerization Evolution Molecular α-Amino acid 03 medical and health sciences Copolymer Genetics Phosphoric Acids Nucleotide Amino Acids Molecular Biology Ecology Evolution Behavior and Systematics 030304 developmental biology chemistry.chemical_classification 0303 health sciences Evolution Chemical Nucleotides Hydrolysis RNA Esters Translation (biology) Hydrogen-Ion Concentration Ribonucleotides Ribosomal RNA Amides Biological Evolution Amino acid chemistry Original Article Peptides |
| Zdroj: | Journal of Molecular Evolution |
| ISSN: | 1432-1432 0022-2844 |
| Popis: | How ribosomal translation could have evolved remains an open question in most available scenarios for the early developments of life. Rather than considering RNA and peptides as two independent systems, this work is aimed at assessing the possibility of formation and stability of co-polymers or co-oligomers of α-amino acids and nucleotides from which translation might have evolved. Here we show that the linkages required to build such mixed structures have lifetimes of several weeks to months at neutral pH and 20 °C owing to the mutual protecting effect of both neighboring phosphoramidate and ester functional groups increasing their stability by factors of about 1 and 3 orders of magnitude, respectively. This protecting effect is reversible upon hydrolysis allowing the possibility of subsequent reactions. These copolymer models, for which an abiotic synthesis pathway is supported by experiments, form a basis from which both polymerization and translation could have logically evolved. Low temperatures were identified as a critical parameter for the kinetic stability of the aminoacylated nucleotide facilitating the synthesis of the model. This observation independently supports the views that any process involving RNA aminoacyl esters, outstandingly including the emergence of translation, was more probable at 0 °C or below and might be considered a kinetic marker constraining the environment in which translation has evolved. Electronic supplementary material The online version of this article (10.1007/s00239-019-9887-7) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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