Is the Distribution of Selenium and Zinc in the Sublocations of Spermatozoa Regulated?
| Autor: | Antonios Kyriakopoulos, Harald Sieme, Dietrich Behne, H. Bertelsmann |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Outer dense fiber endocrine system chemistry.chemical_element Cell Separation Zinc General Biochemistry Genetics and Molecular Biology Selenium chemistry.chemical_compound History and Philosophy of Science Animals Horses Phospholipid-hydroperoxide glutathione peroxidase reproductive and urinary physiology Cell Nucleus chemistry.chemical_classification biology urogenital system General Neuroscience Spermatozoa Protamine Sperm Chromatin chemistry Biochemistry biology.protein Selenoprotein |
| Zdroj: | Annals of the New York Academy of Sciences. 1095:204-208 |
| ISSN: | 0077-8923 |
| Popis: | In the sperm nuclei, of mammalian species selenium has been found only in the form of sperm nuclei glutathione peroxidase (snGPx) where it is most likely bound to the chromatin of spermatozoa. Over 80% of selenium in sperm is bound to the selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) in the midpiece of rat sperm. Zinc in sperm is mainly contained in the outer dense fiber (ODF) proteins of the flagella of mammalian spermatozoa. In the sperm nuclei, zinc is predominately located in the chromatin to the protamine proteins. In order to investigate if the insertion of zinc and selenium in sperm chromatin is regulated, the element concentrations were determined in equine spermatozoa and purified sperm nuclei. We found a significant positive correlation between the selenium concentration in equine spermatozoa and sperm nuclei. The same finding was obtained for the zinc concentration in spermatozoa and sperm nuclei. The results assume that the distribution of selenium and zinc in spermatozoa is regulated by cell signaling pathways and in this way determining the selenium and zinc amount in the chromatin of spermatozoa. |
| Databáze: | OpenAIRE |
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