Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice
| Autor: | Hye Yeon Han, Hyungwoo Kim, Mi Heon Ryu, Geum-San Lee, Junghyun Ryu, Suzy Jo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Cancer Research Dried fruit medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Dermatitis Contact Biochemistry Anti-inflammatory 03 medical and health sciences Interferon-gamma Genetics medicine Animals Molecular Biology Chemokine CCL2 Inflammation Mice Inbred BALB C biology business.industry Plant Extracts Tumor Necrosis Factor-alpha Monocyte Body Weight Ear T helper cell Organ Size biology.organism_classification medicine.disease Bassia scoparia Interleukin-10 030104 developmental biology Cytokine medicine.anatomical_structure Oncology Fruit Immunology Molecular Medicine Tumor necrosis factor alpha Dinitrofluorobenzene Scoparia Epidermis business Spleen Spongiosis |
| Zdroj: | Molecular medicine reports. 13(2) |
| ISSN: | 1791-3004 |
| Popis: | The mature fruit of Kochia scoparia (L.) Schrad. is widely administered in China and Korea as a medicinal herb for treatment of skin diseases, diabetes mellitus and rheumatoid arthritis. The present study investigated the effects of methanol extracts of K. scoparia dried fruit (MEKS) on ear swelling, histopathological changes (such as epidermal acanthosis, spongiosis and immune cell infiltration) and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mice. Topical application of MEKS inhibited DNFB-induced ear thickness and weight increases, as well as DNFB-induced epidermal acanthosis, spongiosis and immune cell infiltration. In addition, treatment with MEKS significantly decreased the levels of tumor necrosis factor-α, interferon-γ and monocyte chemotactic protein-1 in inflamed tissues. These data indicate that the mature fruit of K. scoparia has the potential to be administered for the treatment of inflammatory skin diseases and that the anti-inflammatory action of K. scoparia is involved in the inhibition of type 1 T helper cell skewing reactions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|