Immunization status of Iranian military recruits against Bordetella pertussis infection (whooping cough)
| Autor: | Javad Robat Sarpooshi, Hamid Soheylipoor, Mohammad Mahdi Gooya, Reza Ranjbar, Morteza Izadi, Nematollah Jonaidi Jafari, Shahla Afsharpaiman, Ali Esfahani |
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| Předmět: |
Male
Bordetella pertussis medicine.medical_specialty Adolescent Whooping Cough Enzyme-Linked Immunosorbent Assay Iran Disease cluster Microbiology Young Adult Seroepidemiologic Studies Virology Internal medicine medicine Seroprevalence Humans Medical history Whooping cough Pertussis Vaccine biology business.industry General Medicine medicine.disease biology.organism_classification Antibodies Bacterial Vaccination Infectious Diseases Military Personnel Pertussis Toxin Immunoglobulin G Immunology biology.protein Population study Parasitology Immunization Antitoxins Antibody business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Introduction: Military recruits are susceptible to respiratory pathogens because of increased antibiotic resistance and the lack of an effective vaccine. The goal of the current study was to determine the immunological status of the Bordetella pertussis among conscripts in Iranian military garrisons. Methodology: The study population consisted of 424 conscripts aged 18 to 21 years who enrolled for military service. They were selected using cluster stratified sampling from all military garrisons in Tehra, Iran. To determine the seroprevalence of infection, blood specimens from all recruits were collected and stored at - 20°C until assayed. All serum samples were screened for immunoglobulin G (IgG) antibodies against Bordetella pertussis toxin (PT) and by using enzyme-linked immunosorbent assay (ELISA). Results: The overall prevalence of B. pertussis seropositivity in military recruits was 60.6. Only 55.0% of the recruits had low awareness about the record of vaccination against B. pertussis during childhood. Among 424 studied individuals, 48 recruits (11.3%) had a positive history of whooping cough; prevalence of seropositivity in these recruits was 70.0%. Among these subjects, 61.7% were referred to a physician for treatment and only 39.6% of them were administered anti-pertussis therapy. Conclusions: Our study showed that military conscripts in Tehran garrisons were not serologically immune to pertussis and also confirmed the low awareness about vaccination and medical history related to pertussis infection in this high-risk subgroup of the Iranian population. Routine acellular booster vaccination, particularly before 18 years of age, is recommended. |
| Databáze: | OpenAIRE |
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