Study of the fibrinolytic process in a patient with antiphospholipid syndrome
| Autor: | Jaheli Fuenmayor, Jenny V. Garmendia, Daniela Kanzler, Rita Marchi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty Abortion Habitual medicine.medical_treatment Deep vein Fibrinogen Autoantigens Fibrin Polymerization Thrombin Pre-Eclampsia Antiphospholipid syndrome Nephelometry and Turbidimetry Pregnancy Internal medicine Fibrinolysis Medicine Humans Blood Coagulation Autoantibodies Lupus anticoagulant biology Dose-Response Relationship Drug business.industry Hematology General Medicine Thrombophlebitis medicine.disease Antiphospholipid Syndrome Thrombosis medicine.anatomical_structure Endocrinology beta 2-Glycoprotein I Antibodies Anticardiolipin Immunoglobulin G Lupus Coagulation Inhibitor Tissue Plasminogen Activator biology.protein Female Prothrombin business medicine.drug |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 26(3) |
| ISSN: | 1473-5733 |
| Popis: | The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antibodies against β2-Glycoprotein I (aβ2-GPI), cardiolipin (aCL) and lupus anticoagulant combined with venous or arterial thrombosis and/or foetal losses. A 28-year-old female was positive for aβ2-GPI, aCL, aPT (antibodies against prothrombin) and lupus anticoagulant. She had two miscarriages and a deep vein thrombosis event. The patient plasma fibrinogen and IgG concentrations were two times higher than control. Fibrinolysis was induced in vitro adding tPA, before clotting plasma with 0.03 or 0.6 IU/ml thrombin, and in purified system with normal fibrinogen in the presence of 0.5 mg/ml of patient or normal IgG. The APS patient had 1.5 and 1.9 times higher clot rate formation (CRL) and maximum absorbance (MaxAbsL) at both thrombin concentrations. At 0.6 IU/ml of thrombin, the patient delay on fibrin polymerization onset was corrected. The patient Lys50MA (time needed for 50% clot dissolution) was slower (P |
| Databáze: | OpenAIRE |
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