Total Synthesis of Kibdelomycin
| Autor: | Chi He, Yu Wang, Cheng Bi, David S. Peters, Timothy J. Gallagher, Johannes Teske, Jason S. Chen, Rachel Corsetti, Anthony D'Onofrio, Kim Lewis, Phil S. Baran |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Angewandte Chemie. 134 |
| ISSN: | 1521-3757 0044-8249 |
| Popis: | A modular total synthesis of kibdelomycin is disclosed that should enable structure-activity relationship (SAR) studies of this interesting class of antibiotics. The route uses simple building blocks and addresses lingering questions about its structural assignment and relationship to amycolamicin, a recently described natural product reported to have a similar structure. Initial antibacterial assays reveal that both C-22 epimers (the N-glycosidic linkage) of the natural product have similar activity while structurally truncated analogs lose activity. |
| Databáze: | OpenAIRE |
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