Exploratory relationships between cognitive improvements and training induced plasticity in hippocampus and cingulum in a rat model of mild traumatic brain injury: a diffusion MRI study

Autor: Benedicte Descamps, Kim Braeckman, Christian Vanhove, Karen Caeyenberghs
Rok vydání: 2019
Předmět:
medicine.medical_specialty
Traumatic brain injury
Cognitive Neuroscience
medicine.medical_treatment
neuroplasticity
education
Cognitive neuroscience
Hippocampus
050105 experimental psychology
diffusion MRI
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
Cognition
0302 clinical medicine
Physical medicine and rehabilitation
mild traumatic brain injury
Brain Injuries
Traumatic
Fractional anisotropy
preclinical
medicine
Animals
Cingulum (brain)
Cognitive Dysfunction
0501 psychology and cognitive sciences
Radiology
Nuclear Medicine and imaging
touchscreen cognitive training system
Rehabilitation
Cognitive Behavioral Therapy
business.industry
05 social sciences
Neuropsychology
Brain
medicine.disease
Magnetic Resonance Imaging
Cognitive training
Rats
Disease Models
Animal
Psychiatry and Mental health
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
nervous system
Neurology
Neurology (clinical)
business
030217 neurology & neurosurgery
Zdroj: Brain Imaging and Behavior. 14:2281-2294
ISSN: 1931-7565
1931-7557
DOI: 10.1007/s11682-019-00179-4
Popis: Traumatic brain injury (TBI) is a major cause of long-term cognitive deficits, even in mild TBI patients. Computerized cognitive training can help alleviate complaints and improve daily life functioning of TBI patients. However, the underlying biological mechanisms of cognitive training in TBI are not fully understood. In the present study, we utilised for the first time a touchscreen cognitive training system in a rat model of mild TBI. Moreover, we wanted to examine whether the beneficial effects of a cognitive training are task-dependent and selective in their target. Specifically, we examined the effect of two training tasks, i.e. the Paired Associate Learning (PAL) task targeting spatial memory functioning and 5-Choice Continuous Performance (5-CCP) task loading on attention and inhibition control, on the microstructural organization of the hippocampus and cingulum, respectively, using diffusion tensor imaging (DTI). Our findings revealed that the two training protocols induced similar effects on the diffusion MRI metrics. Further, in the TBI groups who received training microstructural organization in the hippocampus and cingulum improved (as denoted by increases in fractional anisotropy), while a worsening (i.e., increases in mean diffusivity and radial diffusivity) was found in the TBI control group. In addition, these alterations in diffusion MRI metrics coincided with improved performance on the training tasks in the TBI groups who received training. Our findings show the potential of DTI metrics as reliable measure to evaluate cognitive training in TBI patients and to facilitate future research investigating further improvement of cognitive training targeting deficits in spatial memory and attention.
Databáze: OpenAIRE
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