Testing assumptions on prefrontal transcranial direct current stimulation: Comparison of electrode montages using multimodal fMRI
Autor: | Jana Wörsching, Irmgard Heinz, Stephan Goerigk, Christine Bauer, Christian Plewnia, Daniel Keeser, Frank Padberg, Alkomiet Hasan, Birgit Ertl-Wagner |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male Brain activity and meditation medicine.medical_treatment Biophysics Prefrontal Cortex Transcranial Direct Current Stimulation behavioral disciplines and activities tDCS 050105 experimental psychology lcsh:RC321-571 Young Adult 03 medical and health sciences 0302 clinical medicine Outcome Assessment Health Care medicine Humans Single-Blind Method 0501 psychology and cognitive sciences Resting state Prefrontal cortex lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry medicine.diagnostic_test Transcranial direct-current stimulation Resting state fMRI General Neuroscience fMRI 05 social sciences Cognition Neurophysiology Magnetic Resonance Imaging Healthy Volunteers Electrodes Implanted Dorsolateral prefrontal cortex Memory Short-Term medicine.anatomical_structure Cognitive control Neurology (clinical) Functional magnetic resonance imaging Psychology Electrode montage Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Brain Stimulation, Vol 11, Iss 5, Pp 998-1007 (2018) |
ISSN: | 1935-861X |
Popis: | Background Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) has been widely applied in cognitive neurosciences and advocated as a therapeutic intervention, e.g. in major depressive disorder. Although several targets and protocols have been suggested, comparative studies of tDCS parameters, particularly electrode montages and their cortical targets, are still lacking. Objective This study investigated a priori hypotheses on specific effects of prefrontal-tDCS montages by using multimodal functional magnetic resonance imaging (fMRI) in healthy participants. Methods 28 healthy male participants underwent three common active-tDCS montages and sham tDCS in a pseudo-randomized order, comprising a total of 112 tDCS-fMRI sessions. Active tDCS was applied at 2 mA for 20 min. Before and after tDCS, a resting-state fMRI (RS fMRI) was recorded, followed by a task fMRI with a delayed-response working-memory (DWM) task for assessing cognitive control over emotionally negative or neutral distractors. Results After tDCS with a cathode-F3/anode-F4 montage, RS-fMRI connectivity decreased in a medial part of the left PFC. Also, after the same stimulation condition, regional brain activity during DWM retrieval decreased more in this area after negative than after neutral distraction, and responses to the DWM task were faster, independent of distractor type. Conclusion The current study does not confirm our a priori hypotheses on direction and localization of polarity-dependent tDCS effects using common bipolar electrode montages over PFC regions, but it provides evidence for montage-specific effects on multimodal neurophysiological and behavioral outcome measures. Systematic research on the actual targets and the respective dose-response relationships of prefrontal tDCS is warranted. |
Databáze: | OpenAIRE |
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