Testing assumptions on prefrontal transcranial direct current stimulation: Comparison of electrode montages using multimodal fMRI

Autor: Jana Wörsching, Irmgard Heinz, Stephan Goerigk, Christine Bauer, Christian Plewnia, Daniel Keeser, Frank Padberg, Alkomiet Hasan, Birgit Ertl-Wagner
Rok vydání: 2018
Předmět:
Adult
Male
Brain activity and meditation
medicine.medical_treatment
Biophysics
Prefrontal Cortex
Transcranial Direct Current Stimulation
behavioral disciplines and activities
tDCS
050105 experimental psychology
lcsh:RC321-571
Young Adult
03 medical and health sciences
0302 clinical medicine
Outcome Assessment
Health Care
medicine
Humans
Single-Blind Method
0501 psychology and cognitive sciences
Resting state
Prefrontal cortex
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
medicine.diagnostic_test
Transcranial direct-current stimulation
Resting state fMRI
General Neuroscience
fMRI
05 social sciences
Cognition
Neurophysiology
Magnetic Resonance Imaging
Healthy Volunteers
Electrodes
Implanted
Dorsolateral prefrontal cortex
Memory
Short-Term
medicine.anatomical_structure
Cognitive control
Neurology (clinical)
Functional magnetic resonance imaging
Psychology
Electrode montage
Neuroscience
030217 neurology & neurosurgery
Zdroj: Brain Stimulation, Vol 11, Iss 5, Pp 998-1007 (2018)
ISSN: 1935-861X
Popis: Background Transcranial direct current stimulation (tDCS) of the prefrontal cortex (PFC) has been widely applied in cognitive neurosciences and advocated as a therapeutic intervention, e.g. in major depressive disorder. Although several targets and protocols have been suggested, comparative studies of tDCS parameters, particularly electrode montages and their cortical targets, are still lacking. Objective This study investigated a priori hypotheses on specific effects of prefrontal-tDCS montages by using multimodal functional magnetic resonance imaging (fMRI) in healthy participants. Methods 28 healthy male participants underwent three common active-tDCS montages and sham tDCS in a pseudo-randomized order, comprising a total of 112 tDCS-fMRI sessions. Active tDCS was applied at 2 mA for 20 min. Before and after tDCS, a resting-state fMRI (RS fMRI) was recorded, followed by a task fMRI with a delayed-response working-memory (DWM) task for assessing cognitive control over emotionally negative or neutral distractors. Results After tDCS with a cathode-F3/anode-F4 montage, RS-fMRI connectivity decreased in a medial part of the left PFC. Also, after the same stimulation condition, regional brain activity during DWM retrieval decreased more in this area after negative than after neutral distraction, and responses to the DWM task were faster, independent of distractor type. Conclusion The current study does not confirm our a priori hypotheses on direction and localization of polarity-dependent tDCS effects using common bipolar electrode montages over PFC regions, but it provides evidence for montage-specific effects on multimodal neurophysiological and behavioral outcome measures. Systematic research on the actual targets and the respective dose-response relationships of prefrontal tDCS is warranted.
Databáze: OpenAIRE
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