Alpha1-Antitrypsin Deficiency and Pregnancy
| Autor: | M C McCoy, Vern L. Katz, Jeffrey A. Kuller, Cynthia Bristow |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
medicine.medical_specialty Genotype Physiology Disease Asymptomatic Obstetric Labor Premature Pregnancy alpha 1-Antitrypsin Deficiency Internal medicine medicine Humans Risk factor Alpha 1-antitrypsin deficiency business.industry Infant Newborn Obstetrics and Gynecology Heterozygote advantage medicine.disease Pregnancy Complications Endocrinology alpha 1-Antitrypsin Pediatrics Perinatology and Child Health Gestation Female medicine.symptom business |
| Zdroj: | American Journal of Perinatology. 12:303-305 |
| ISSN: | 1098-8785 0735-1631 |
| DOI: | 10.1055/s-2007-994480 |
| Popis: | Alpha1-antitrypsin deficiency is an inherited pulmonary disorder which results from a deficiency of a major plasma protease inhibitor. The onset and severity of symptoms vary widely and depend on the genotype and whether the patient smokes cigarettes. Alpha1-antitrypsin in pregnancy has only been previously reported twice. Our patient had a functional serum alpha1-antitrypsin level which was 15% of normal but was clinically asymptomatic and she did not smoke. Her genotype revealed a non-ZZ pattern. Her obstetric history was complicated by preterm labor in each of her five ongoing pregnancies. Alpha1-antitrypsin deficiency is inherited via two codominant autosomal genes. Although there is great variability in severity of disease, seriously affected patients may have emphysema and hepatic abnormalities. Patients with non-ZZ genotypes or who are heterozygotes may have favorable pregnancy outcomes. |
| Databáze: | OpenAIRE |
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