Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumors
| Autor: | William A. Smithson, Paula J. Schomberg, Joseph P. Neglia, Robert V. Groover, Jan C. Buckner, Judith R. O'Fallon, Prema P. Peethambaram, Edward G. Shaw, Corey Raffel, David W. Kimmel |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.drug_class Vomiting medicine.medical_treatment Phases of clinical research Gastroenterology Chorionic Gonadotropin Central Nervous System Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols Medicine Humans Prospective Studies Prospective cohort study Child Etoposide Cisplatin Chemotherapy business.industry Remission Induction Radiotherapy Dosage medicine.disease Combined Modality Therapy Hematologic Diseases Surgery Radiation therapy Oncology Female Germ cell tumors Germinoma alpha-Fetoproteins Gonadotropin business medicine.drug |
| Zdroj: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 17(3) |
| ISSN: | 0732-183X |
| Popis: | PURPOSE: A prospective phase II study was initiated to assess the response rate, survival, and late effects of treatment in patients with newly diagnosed CNS germ cell tumors (GCT), using etoposide plus cisplatin followed by radiation therapy prescribed by extent of disease, histology, and response to chemotherapy. PATIENTS AND METHODS: Seventeen patients aged 8 to 24 years with histologically proven CNS GCT received etoposide (100 mg/m2/d) plus cisplatin (20 mg/m2/d) daily for 5 days every 3 weeks for four cycles, followed by radiation therapy. Nine patients had germinomas; eight had mixed GCT. Four patients (three with germinomas and one with mixed GCT) presented with leptomeningeal dissemination. RESULTS: Radiographically, 14 of 17 patients were assessable for response; 11 patients experienced complete regression, and three had major partial regression before radiation. Six of seven assessable patients with elevated CSF levels of alpha-fetoprotein or beta–human chorionic gonadotropin had normalization with chemotherapy alone; all normalized with combined chemotherapy and radiation therapy. All 17 patients are alive without evidence of disease (median follow-up, 51 months). One patient developed a relapse in the spinal leptomeninges and was rendered free of disease with spinal radiation more than 5 years ago. One patient developed carotid stenosis requiring surgery. Thus far, only minimal long-term deterioration in neurocognitive function has been detected as a consequence of protocol treatment. CONCLUSION: Conventional-dose intravenous chemotherapy with etoposide and cisplatin can effect tumor regression in a high proportion of patients with CNS GCT, including those with leptomeningeal metastases. Acute and long-term toxicities are acceptable. Progression-free survival and overall survival are excellent. |
| Databáze: | OpenAIRE |
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